用3月龄去卵巢SD大鼠为模型，4.5mg／L已烯雌酚（diethylstilbestoli，DES）和1kg／L黄芪水提液5mL／kg·dig，每周6次，持续12周，胫骨近端不脱钙骨片测量。结果：去卵巢组大鼠的骨形成和骨吸收均增加，但骨吸收大于骨形成，骨质丢失（％Tb.Ar—68％）；黄芪水提液和DES能有效防止去卵巢大鼠的骨丢失，效应相近（与去卵巢组比较％Tb.Ar分别＋122％和＋85％，两个治疗组间P＞0.05），但作用机理不同。黄芪水提液仅抑制去卵巢后的骨吸收，而DES则同时抑制骨吸收和骨形成，但以抑制骨吸收为主。

SD rats n-32,3-month-old,were randomly divided in groups of basal control,aging control,ovariectomiaed(OVX),OVX+DES(Diethylstilbestrol)5 mL/kg?d(4. 5mg/L)and OVX+Astragalus mem- branaceus 5mL/kg. d(1 kg/L) ig,6 times a week. After 12 weeks ,their proximal tibiae were processed to un- decalcified sections at 20 hem thickness for histomorphometric analysis. Results ; trabecullar bone mass in the OVX group reduced markedly(%Tb. Ar一68 0 o) due to bone turnover increase with bone resorption exceeded bone formation. Treatment with Huangqi and DES increased significantly the bone mass(0 o Tb. Ar+12200 and +850o respectively) as compared with OVX control. The protective effects of the two drugs appeared to be quite similar but the mechanism involved may be different. Huangqi suppresses principally bone resorption while DES inhibits bone resorption as well as bone formation. Conclusion;Results of the study showed that Huangqi and DES could prevent trabecular loss in OVX rats.

国家自然科学研究基金!39470367