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[摘要]
从何首乌(Polygonum multiflorum Thunb.)的根中分离出11个化合物,根据光谱学分析分别鉴定为:大黄酚(chrysophanol,Ⅰ)、大黄素甲醚(physcione,Ⅱ)、大黄素(emodin,Ⅲ)、ω-羟基大黄素(citreorosein,Ⅳ)、大黄酚8-O-β-D-吡喃葡萄糖苷(chrysophanol8-O-β-D-glucopyranoside,Ⅴ)、大黄素甲醚8-O-β-D-吡喃葡萄糖苷(Physcione8-O-β-D-glucopyranoside,Ⅵ)、大黄素8-O-β-D-吡喃葡萄糖苷(emodin8-O-β-D-glucopyranoside,Ⅶ)、决明酮8-O-β-D-吡喃葡萄糖苷(torachrysone8-O-β-D-glucopyranoside,Ⅷ)、2,3,5,4′-四羟基芪2-O-β-D-吡喃葡萄糖苷(2,3,5,4′-tetrahydroxystilbene2-O-β-D-glucopyranoside,Ⅸ)、没食子酸甲基酯(methylgallate,Ⅹ)和吲哚-3-(L-α-氨基-α-羟基内酸)甲酯[Indole-3-(L-α-amino-α-hydroxypropionicacid)methylester]。其中,化合物Ⅺ为新的天然产物。上述蒽醌和萘类化合物以及芦荟大黄素(aloe-emodin,Ⅻ)、大黄酸(rhein,)、芦荟大黄素8-O-β-D-吡喃葡萄糖苷(aloe-emodin8-O-β-D-glucopyranoside,)、大黄酚8-O-β-D-(6′-O-丙酰基)吡喃葡萄糖苷(chrysophanol8-O-β-D-(6′-O-malonyl)glucopyranoside , XV) 、 番泻叶昔A(sennoside A , XVI) 、 和番泻叶昔 B(sennoside ,X)在100μmol/L 离体 条件下 , 对重组HIV-1 (Reeombinant HIV-l)蛋白酶活性无抑制作用 。
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[Abstract]
From the root of Polygonum multiflorum Thunb. a new indole derivative,named In dole- 3 (L-α-amino-a-hydroxy propionic acid)methyl ester (Ⅺ), was isolated together with the ten known compounds,chrysophanol (Ⅰ), physcione (Ⅱ), emodin (Ⅲ),citreorosein (Ⅳ), chrysophanol 8-O-β-D-glucopyranoside (Ⅴ), physcione 8-O-β-D-glucopyranoside (Ⅵ),emodin 8-O-β-D-glucopyranoside (Ⅶ), torachrysone 8-O-β-D-glucopyranoside (Ⅷ), 2, 3, 5, 4' -tetrahydroxystilbene2-O-β-Dglucopyranoside(Ⅸ),and methylgallate (Ⅹ). Their structures were determined by spectroscopic means. These anthraquinone compounds and aloe-emodin(Ⅻ),rhein(Ⅻ),aloe-emodin 8-O-β-D glucopyranoside, chrysophanol 8-O-β-D- (6'-O-malonyl)glucopyranoside , sennoside A and sennoside B had no inhibitory effect against recombinant HIV-1 protease at concentration of 100 μmol/L in vitro.
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