根据中草药提取过程的机理建立了提取过程的数学模型,并以当归芍药散有效成分的提取过程为例,根据实验数据应用参数估值方法对数学模型中的参数进行估值。结果表明该模型的计算值与实验值吻合得很好。进一步应用该模型对各操作条件对提取率的影响进行了模拟研究,并应用最优化算法求取使利润目标最大的优化操作条件。研究结果表明,数学模拟及优化方法对改进中草药的提取生产有重要的推动作用。

The purpose of this paper is to illustrate how to use the computer simulation and optimization technology to discribe,analyse and improve the herb extraction process. Based on the mass transfer principle,a mathmatical model of herb extraction process is presented. The modification parameters in the model are predicted by parameter estimation method in order to match the experimental data with the model calculated values. By applying the simulation and optimization of the presented model,the effects of the operating conditions on the yeild radio of effective compounds in the herb extraction process can be investigated. A case study for the paeoniflorin extraction process was presented. The simulation results showed a perfect matching between the experimental data and calculated values. The results also indicated the extended application prospects of the simulation and optimization technology in the modernization of medicinal herb extraction production.