氧前胡素(OP)ig300和600mg/kg抑制乙酸提高小鼠腹腔毛细血管通透性,二甲苯引起的小鼠耳壳肿胀和正常小鼠墨水胃肠推进率,也减少蓖麻油或番泻叶引起的小鼠腹泻次数和发生率.这些作用都存在着剂量依赖性,提示抗炎和抑制胃肠推进运动是氧前胡素的抗腹泻机理.

Oxypeucedanin(OP)300 and 600mg/kg ig inhibited the increased permeability of intraperitoneal blood capillary induced by ip 0.7% acetic acid in mice,xylene-induced swelling of mouse ear,retarded gastrointestinal propellant rate of charcoal ink in normal mice,and reduced the incidence and frequency of purging induced by castor oil or senna in mice.These actions were enhanced in a dose-dependent manner.It is suggested that the antidiarrheal effect of OP is relative to its restriction against inflamation and gastrointestinal propellant function.