实验考察了伸筋草注射液制备过程中特别是超滤精制时药液的pH值、浓度等条件对注射液质量的影响,发现较强酸性、较低浓度的药液在超滤时有效成分的滤过率高,反之则滤过率低,并依此制定出一种能在不同条件下分别除去药液中的大分子杂质和小分子杂质的新的精制方法──两步超滤法,提高了注射剂的质量,减少了有效成分的损失.文中还对两步超滤法的机理进行了初步探讨.

Experiments on the preparation of Shenjincao (Palhinhaea cernua L.)Franco et Vasc.jinjection by ultrafiltration was carried out.Innuence of pH and concentration on the quality of the prepared injection was investigated.It was found that the filterability of active principles was higher at lower pH and concentration,and vice versa.Therefore,a double ultrafiltration process was developed accordingly,which can remove macro and micro molecular impurities from the solution under different conditions.The quality of the injection was improved and loss of active principles was reduced to a minimum.Mechanism of the double ultrafiltration was briefly discussed.

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