[关键词]
[摘要]
将伸筋草提取液分别用超滤法和水醇法制成注射液,分组对染尘大鼠腹腔注射给药5周,解剖后测定各组大鼠肺的鲜重、干重、胶原含量和病理分级等指标,结果表明.用超滤法制备的注射液预防性治疗给药对大鼠实验性矽肺有较好疗效,而用水醇法制备的注射液疗效不佳。还对伸筋草的抗矽有效成分进行了探讨。
[Key word]
[Abstract]
Shenjincao injection was prepared from the extract of Lycopodium cernuum L. by ultrafiltration or wateralcohol methods,respectively,and then injected intra-peritoneally in groups of rats contaminated with quartz powder to assess their prophylactic effects. After 5 weeks of treatment,the rats were dissected and the fresh and dried weights,collagen content and the pathologic grading of the lungs were examined. Results showed that Shenjincao injection prepared with ultrafiltration was effective for the prophylactic treatment of experimental silicnsis of rats,while that prepared with water-alcohol method was devoid of such effect. The antisilicosis active principle of Shenjincao was explored and discussed.
[中图分类号]
[基金项目]
铁道部“八五”重点卫生科研课题