通过观察化学发光及检测H2O2产生,考察锦灯笼的主要成分酸浆苦素B(PhysalinB,PhB)对调理酵母多糖激活的多形核中性粒细胞(polymorphonuclearleukocyte,PMN)的影响。结果显示,不同浓度的PhB对活化的PMN化学发光呈剂量相关的抑制作用,同时对活化PMNH2O2的产生也有相同趋势的抑制作用。提示锦灯宠抗炎机理可能是抑制PMN氧自由基的产生和释放而发挥作用。

Effect of opsonized zpoosan on polymorphonuclear leukocyte (PMN)were studied by chemilundnescence (CL)and hydrogen peroxide (H2O2)assays. Results showed that different concentrations of Physalin B(PhB) presented a dose-dependent inhibitive effect on CL and H2O2 production of activated PMN. It suggested that the anti-inflammatory action of PhB may be related to the inhibition of production and release of oxygen free radical by PMN.