麻醉开胸犬经12指肠给予莱葛冲剂8.5、17g/kg,30～45min后可见SBP、DBP、MAP,HR,LVSP,+dp/dtmax,和TPVR明显降低,约持续90～150min,而－dp/dtmax,LVEDP,CO,CI,SV,SI无明显改变。4.25g/kg对上述诸指标均无明显影响。提示莱葛冲剂对麻醉开胸犬具有明显降压作用,主要与其减慢心率,减弱心肌缩力及降低血管阻力有关。

Hemodynamic effects of Laigechongji(LGCJ)were studied in anesthetized open-chest dogs.LGCJ(in dose of 8.5 and 17. 0g/kg,id. )decreased significantly SBP.DBP MAP,HR,LVSP,+dp/dt maxand TPVR,30~45 mins after medication,and continued for about 90-150mins. However, they had no significant effects on dp/dt maX LVEDP.C(>.II.SV and SL These results suggest that LGCJ may cause hypotension,and its hypotensive effects may be related to its bradycardiac,neqative inotropic and vascular resistance reducing activities.