用⁴⁵Ca跨膜流动测定结果：红花提取物浓度为5、50、500μg／ml时，不影响大鼠主动脉静息状态下Ca^2＋内流；对去甲肾上腺素（NE：12×10^-6mol／L）和高钾溶液（KCl：100mmol／L）引起的Ca^2＋内流，则具有不同程度的阻滞作用，并具有剂量－效应关系（即红花提取物浓度增高，Ca^2＋内流相应减少）。红花与钙拮抗剂verapamil的作用规律相似。说明能阻滞血管平滑肌细胞膜上的受体操纵钙通道（ROC）和电压依赖钙通道（PDC），是红花治疗冠心病的机理之一。

Influence of Carthamus tinctorius L, has been studied on Ca²⁺transmernbrane influx in rataorta when its extract was used at 5, 50, 500 μg/ml. It was shown that the resting⁴⁰Ca influx in rataorta ring was not altered by C,tinctorius but the ⁴⁰Ca influx evoked by norepinephrine(1,2x10^-4mol/L)and KC1 solution(100mmo1/L)was inhibited in a concen-tration-dependent manner, The results demonstrated that the receptor-operated Caz' cha-nnel(ROC)and potential-dependent Ca²⁺ channel(PDC)in cell membrane of smooth mns-cle could be blocked by C.tinctorus as well as by verapamil,

核工业科学基金