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[摘要]
G9315是从胀果甘草中提取的含有6个黄酮体的混合物。2mg剂量明显抑制二甲基苯蒽(DMBA)合并巴豆油诱发的小鼠皮肤乳头瘤的生成, 表现出较强的抗促癌作用。10μg/ml显著抑制巴豆油诱发的Wistar大鼠中性粒细胞化学发光(chemiluminescence, CL), 20μg/ml明显抑制巴豆油诱发的Balb/c新生小鼠皮肤表皮细胞和Balb/c小鼠肝线粒体的CL, 显著对抗巴豆油诱发的Balb/c小鼠肝线粒体的脂质过氧化、使丙二醛(MDA)产量明显减少。
[Key word]
[Abstract]
G9315was a complex extracted from Glycyrrhizae inflate Batal, and consisted of 6 flavovoids with significant antioxidant effects, At 2mg dose, it showed strong antipromoting effect on two stage carcinogenesis in mouse skin induced by DMBA plus croton oil. AtlOPg/ml dose, it inhibited the chemiluminescence(CL)of polymorphonuclear leukocyte(PMN)of Wistar rat induced by croton oil, at 2o ug/ml, it inhibited the CL of new born Balb/c mouse epidermis and liver mitochondria induced 6Y croton oil, It also inhibited the CL of Balb/c mouse microsome induced by CCI, .
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