粗壮女贞叶提取物静脉注射0.098、0.140和0.200g/kg可使麻醉大鼠的血压显著下降, 峰值下降37.7％、38.6％和50.2％:灌胃给药(ig)1.36g/kgqd×3d, 不影响清醒大鼠的血压。清醒自发性高血压大鼠ig1.08和2.16g/kgqd×5d, 血压由24.3±0.5和24.3±0.6降至18.1±0.9和16.6±0.7kPa, 降压作用显著(P＜0.001, ＜0.001)；对清醒二肾-夹型高血压大鼠, ig粗壮女贞0.5g/kgqd×7d, 血压由20.3±3.9降至16.2±3.9kPa, 血压下降20％。以上结果提示具有降压作用。昆明小鼠急性毒性试验, ig49g/kg10d内动物生长良好, 未出现死亡；腹腔注射5个剂量组(每组10只)按简化机率单位法测得LD502.64±0.21g/kg(P＝0.95)。

When an extract of the leaves of Ligustrum ro6ustum was given to anesthetized tats intravonously at doses of 0, 098, 0, 140, 0, 200 g/kgthe BP of the animals decreased rapidly by 37.7, 38, 6 and 50.2% respectively, Bu twithout any effect when given intragastrically to conscious rats at 1, 36/kg(qid x3d}.Wnen conscious spontaneous hypertensive rats were given this extract intragastrically at 1, 08 and 2.16g/kg(qidx5d}their BP decreased to 18, 110, 9 and 16, 610, 7kPa from 24.3±0.5 and 24.3上O.6kPa res pectively(P<0.001, P<0.001).when 2 kidney 1clip hypertensive rats were treated with tliis extract ig at 0.5g/kg

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