目的 探讨多巴胺D3受体拮抗剂苯并噻唑啉-2-酮-甲酰胺类化合物Y-QA31对甲基苯丙胺（METH）诱导的大鼠条件位置偏爱（CPP）效应的影响。方法 通过CPP实验，以METH为阳性药，观察Y-QA31（12.5、25、50 mg/kg，ip）自身致CPP潜力；通过CPP实验建立大鼠METH精神依赖模型，观察Y-QA31（6.25、12.5、25、50 mg/kg，ip）预处理是否干预模型的形成、表达、复吸。结果 0.5 mg/kg METH可诱导大鼠产生明显的CPP；Y-QA31自身不能诱导大鼠形成CPP；伴随给予Y-QA31不能阻止METH诱导大鼠CPP的形成；表达期单次给予Y-QA31能剂量依赖性降低METH诱导的大鼠CPP的表达；Y-QA31可抑制METH诱导大鼠CPP的复吸。结论 Y-QA31能抑制METH的奖赏效应，在成瘾治疗中发挥一定作用。

Objective To study the effect of compound of Benzothiazoline-2-ketone-formamide:Y-QA31 on conditioned place preference (CPP) induced by methamphetamine (METH). Methods The CPP potential of Y-QA31 (12.5, 25 and 50 mg/kg, IP) was observed by the CPP experiment and METH as the positive drug. METH-induced CPP was established in rats. The acquisition, expression and reinstatement of CPP was influenced by Y-QA31 (6.25, 12.5, 25 and 50 mg/kg, ip). The results of each group were compared and analzsed. Results 0.5 mg/kg METH induced cpp; (1) Y-QA31 failed in inducing CPP in rats; (2) repetitive injection of YQA31(daily during the METH conditioning)did not alter the acquisition of METH-induced CPP; (3) a single injection of YQA31 (prior to CPP test) dose-dependently attenuated the expression of METH-induced CPP; (4) a single injection of YQA31 decreased the reinstatement of METH-induced CPP. Conclusion Y-QA31 can inhibit the rewarding effect induced by METH and may play a role in the treatment of METH addiction.

国家“重大新药创制”科技重大专项（2017ZX09101-005-007、2016ZX08011007、2017ZX09201008-001-002、ZDYZ2015-2）