Qingwei San is recorded in Lanshi Micang written by Li Dongyuan of Jin Dynasty. It consists of five traditional Chinese medicines:Angelica sinensis Radix, Rehmannia Radix, Coptis Rhizoma, Cortex Moutan, Rhizoma Cimicifugal. It is a common prescription for treating stomach fire and toothache. In recent years, clinical researches have shown that the prescription of Qingwei San has wide clinical application. Through literature review, this paper elaborates the prescription source, efficacy, chemical composition, pharmacological research, clinical application,in order to provide evidence for new drug research and development.