中药血清药物化学是通过对实验动物口服给药后的含药血清进行分析，对药效物质基础及复方配伍机制进行快速筛选的一项新型技术，在中药质量控制、中药炮制研究等领域都发挥重要作用。随着不断的发展创新，将其与血清药理学、药动学等学科相互融合，为中药及复方的研究提供了更加完善的手段。对中药血清药物化学的主要技术手段、应用研究及其与一些学科的联合使用现状进行综述，为中药血清药物化学的发展提供新的研究思路。

Serum pharmacochemistry of traditional Chinese medicine (TCM) is a new technique for rapid screening of effective material basis and compound compatibility mechanism by analyzing the serum containing drugs after oral administration in experimental animals. It plays an important role in the quality control of traditional Chinese medicine, the processing of traditional Chinese medicine and other fields. With the continuous development and innovation, it is integrated with serum pharmacology, pharmacokinetics and other disciplines, which provides a more perfect means for the study of traditional Chinese medicine and compound prescription. In this paper, the main technical means and applied research of serum pharmacochemistry of traditional Chinese medicine and its combined use with some disciplines are reviewed, which provides a new research idea for the development of serum pharmacochemistry of traditional Chinese medicine.With the continuous development and innovation, it is integrated with serum pharmacology, pharmacokinetics and other disciplines, which provides a more perfect means for the study of traditional Chinese medicine and compound prescription. In this paper, the main technical means and applied research of serum pharmacochemistry of traditional Chinese medicine and its combined use with some disciplines are reviewed, which provides a new research idea for the development of serum pharmacochemistry of traditional Chinese medicine.

山西省重点研发项目（项目编号：201603D321028）