目的 探讨米索前列醇联合依沙吖啶在中晚期妊娠引产中的应用效果。方法 选取西安交通大学附属3201医院2012年1月—2017年12月收治的138例中晚期妊娠引产患者，按引产方式分为对照组、观察组，各69例。对照组使用乳酸依沙吖啶注射液进行引产，观察组在对照组的基础上联合使用米索前列醇进行引产。比较两组引产效果、胎儿娩出时间、阴道出血量及不良反应的发生情况。结果 观察组引产有效率是100%，显著高于对照组的91.75%（P<0.05）。观察组胎儿娩出时间<35 h的人数占比显著高于对照组（P<0.05）。观察组患者阴道出血量显著低于对照组（P<0.05），两组不良反应的发生率间差异不显著。结论 米索前列醇联合依沙吖啶在中晚期妊娠引产中的效果较好，可显著提高引产有效率、缩短胎儿娩出时间，值得临床应用。

Objective To explore the clinical efficacy of combined use of ethacridine and misoprostol in induction of labor in middle and late pregnancy.Methods Selected 138 patients with with induction of labor in the middle and late pregnancy from January 2012 to December 2017 in our hospital. All patients were divided into control group and observation group by induction of labor, each of group of 69 cases. Control group used induction of lactate ethacridine injection, the observation group combined with misoprostol for induction of labor based on the control group. The effects of induced labor, fetal delivery time, vaginal bleeding and adverse reactions in the two groups were compared. Results The effective rate of induction of labor in the observation group was 100%, which was significantly higher than that of the control group (91.75%) (P<0.05). The proportion of the fetus whose delivery time was < 35 h in the observation group was significantly higher than that in the control group (P<0.05). The amount of vaginal bleeding in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusions The combination of ethacridine and misoprostol is effective in induction of labor in middle and late pregnancy. It can significantly improve the induction efficiency and shorten the delivery time of fetus. It is worthy of clinical application.