目的 对灯盏细辛注射液联合常规药物治疗糖尿病周围神经病变临床疗效和安全性进行系统评价。方法 计算机检索中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、维普中文科技期刊数据库（VIP）、万方医学期刊全文数据库、PubMed、Embase、Cochrane library等数据库，检索日期截止到2018年8月19日。根据Cochrane系统评价的方法进行纳入研究的筛选，提取数据和质量评价，然后采用Revman 5.3软件进行Meta-分析。结果 共有23项研究最终进入本系统评价，Meta-分析结果显示灯盏细辛注射液联合常规治疗组患者的临床有效率明显优于单纯常规治疗组（RR=1.42，95% CI=1.28~1.57，P<0.000 01）；在尺神经运动神经传导速度、腓神经运动神经及感觉神经传导速度、正中神经运动神经及感觉神经传导速度改善方面，灯盏细辛注射液联合常规药物优于单纯常规药物治疗。在尺神经感觉神经传导速度改善方面，两组比较无统计学差异。结论 灯盏细辛注射液联合常规药物比单纯常规药物治疗在改善糖尿病周围神经病变临床结局上更有优势。

Objective Systematic evaluation of clinical efficacy and safety of Dengzhan Xixin Injection combined with conventional drugs in the treatment of diabetic peripheral neuropathy. Methods Computer retrieval of CNKI, CBM, VIP, Wanfang Database, PubMed, Embase, Cochrane library was conducted until August 19, 2018. The methods of Cochrane systematic evaluation were used to screen the included studies, extract data and do quality evaluation, and Revman 5.3 software was then used for Metaanalysis. Results A total of 23 studies were finally included in the system evaluation, and the results of Meta-analysis showed that the clinical efficiency of patients in the Dengzhanxixin Injection combined with conventional treatment group was significantly superior to that in the simple conventional treatment group (RR=1.42, 95%CI=1.28-1.57, P<0.000 01). In the improvement of ulnar nerve motor conduction velocity, peroneal nerve motor and sensory nerve conduction velocity, median nerve motor and sensory nerve conduction velocity, Dengzhanxixin Injection combined with conventional drugs is superior to simple conventional treatment. There was no statistical difference between the two groups in the improvement of ulnar nerve conduction velocity. Conclusion Dengzhan Xixin Injection combined with conventional drug is superior to conventional drug therapy in improving the clinical outcomes of diabetic peripheral neuropathy.

北京市中医管理局资助项目（JJ2016-15）；北京市医院管理局重点医学专业发展计划建设项目（ZYLX201812）