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[摘要]
目的 探讨阿莫西林联合奥美拉唑治疗消化性溃疡合并上消化道出血的临床治疗效果。方法 选取2017年3月-2018年3月在上海市嘉定区安亭医院收治的消化性溃疡合并上消化道出血患者80例,采用随机数字法分为观察组(40例)和对照组(40例),对照组患者仅给予奥美拉唑进行治疗,观察组患者在对照组基础上联合阿莫西林治疗,治疗疗程均为14 d。比较两组患者的临床基线数据、治疗有效率和不良反应发生率,及住院时间、出血量、潜血转阴时间。结果 观察组患者的治疗有效率为87.50%,对照组患者的治疗有效率为65.00%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为10.00%,对照组患者不良反应发生率为27.50%,差异具有统计学意义(P<0.05)。与对照组相比,观察组患者的住院时间及潜血转阴时间均显著缩短,而出血量显著减少,差异具有统计学意义(P<0.05)。结论 阿莫西林联合奥美拉唑能够有效改善消化道溃疡合并上消化道出血的临床症状,临床效果较好,且不良反应的发生率较低。
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[Abstract]
Objective To investigate the clinical therapeutic effect of omeprazole combined with amoxicillin in the treatment of peptic ulcer combined with upper gastrointestinal bleeding. Methods Totally 80 cases peptic ulcer combined with upper gastrointestinal bleeding patients were collected from March 2017 to March 2018 in our hospital, according to the random number divided into treatment group (40 cases) and control group (40 cases), the control group was given omeprazole, the treatment group was given omeprazole combined with amoxicillin, compared with the clinical baseline data, effect rate of clinical treatment, incidence of adverse reaction, hospital stays, the amount of bleeding and occulting blood negative time of the two groups.Results The effect rate of clinical treatment of treatment group was 35 cases (87.50%), the effect rate of clinical treatment of control group was 26 cases (65.00%), the difference was statistically significant (P<0.05). The incidence of adverse reaction of the treatment group was four cases (10.00%), the incidence of adverse reaction of the control group was 11 cases (26.50%), the difference was statistically significant (P<0.05). Compared with the control group, the hospital stays and occulting blood negative time both significantly shorten, and the amount of bleeding significantly decreased.Conclusion Omeprazole combined with amoxicillin can significantly improve the clinical symptoms of peptic ulcer combined with upper gastrointestinal bleeding, the clinical effect is high, and the incidence of adverse reaction is low.
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