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目的 探讨盐酸氨溴索雾化治疗新生儿肺炎的临床疗效及对患儿炎症因子的影响。方法 选取2016年1月-2018年5月于蚌埠市第一人民医院住院治疗的新生儿肺炎患儿100例,采用随机数字法分为对照组和观察组,每组50例,对照组给予常规治疗,观察组在常规治疗基础上给予盐酸氨溴索雾化吸入。治疗7 d后比较两组患者的临床治疗有效率、肺部啰音消失时间、呼吸困难消失时间及咳嗽消失时间,并采用酶联免疫吸附测定法测定血清白介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)的水平。结果 观察组患儿的临床总有效率为94.00%,对照组患儿的临床总有效率为76.00%,差异具有统计学意义(P<0.05)。与对照组相比,观察组患者的肺部啰音消失时间、呼吸困难消失时间及咳嗽消失时间均显著缩短,差异具有统计学意义(P<0.05)。治疗后,两组患者的IL-6、CRP及TNF-α均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组患者的IL-6、CRP及TNF-α均显著低于对照组,差异具有统计学意义(P<0.05)。观察组患儿不良反应发生率为8.00%,对照组患儿不良反应发生率为10.00%,差异无统计学意义。结论 盐酸氨溴索雾化治疗可显著改善新生儿肺炎的临床症状,有效降低患儿的炎症因子水平,治疗效果较好。
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[Abstract]
Objective To investigate the clinical effect of ambroxol in the treatment of newborn pneumonia and its effect of inflammatory factor of child patient.Methods 100 cases newborn pneumonia patients were corrected from January 2016 May 2018 in First people's hospital of Bengbu, according to the random number method divided into control group and treatment group, with 50 cases in each group, the control group was given routine treatment, the treatment group was given ambroxol hydrochloride injection on the basis of routine treatment, compared with the effective clinical treatment, lung murmur goes out of time, breathing difficulties disappear time and cough disappearance time of the two groups, and tested the serum level of interleukin 6, C-reactive protein and tumornecrosis factor alpha by enzyme linked immunosorbent assay.Results The clinical total effective rate of the child patient with treatment group was 94.00%, the clinical total effective rate of the child patient with control group was 76.00%, the difference was statistically significant (P<0.05). Compared with the control group, the lung murmur goes out of time, breathing difficulties disappear time and cough disappearance time both significantly shortened, the difference was statistically significant (P<0.05). Before treatment, compared with the IL-6, CRP and TNF-α of the treatment and control group, the difference was not statistically significant. After treatment, the IL-6, CRP and TNF-α of the treatment group significantly lower than control group, the difference was statistically significant (P<0.05). The incidence of adverse reaction of the child patient with treatment group was four cases (8.00%), the incidence of adverse reaction of the child patient with control group was five cases (10.00%), the difference was not statistically significant.Conclusion Ambroxol can significantly improved the clinical symptoms of newbornpneumonia, and can effectively reduce the level of inflammatory factors in children and has good therapeutic effect.
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