目的 研究礞石滚痰丸联合哌罗匹隆对精神分裂症患者血清生化指标的影响。方法 选择2015年1月-2017年12月南阳市第四人民医院收治的300例精神分裂症患者，随机分为两组。对照组单纯口服哌罗匹隆，观察组联合口服礞石滚痰丸。两组均治疗6周。比较两组治疗前后的阳性和阴性症状量表评分（PANSS）和血清生化指标改变情况。结果 与对照组临床有效率78.00%比较，观察组临床有效率92.67%显著高于对照组（P<0.05）。治疗后，两组PANSS评分均显著降低（P<0.05）；且观察组PANSS评分显著低于对照组（P<0.05）。治疗后，两组血清皮质醇（Cor）、神经生长因子（NGF）、脑源性神经营养因子（BDNF）水平均显著降低（P<0.05），血清5-羟色胺（5-HT）水平均显著升高（P<0.05）；且观察组血清Cor、NGF、BDNF水平显著低于对照组，5-HT水平显著高于对照组（P<0.05）。对照组不良反应的发生率为36.0%，观察组为35.3%，对比无明显的差异。结论 礞石滚痰丸联合哌罗匹隆对精神分裂症患者具有较为显著的治疗效果，其作用机制可能与降低血清Cor、NGF、BDNF水平，提高血清5-HT水平有关。

Objective To study the effect of Mengshi Guntan Wan combined with perperone on serum biochemical indexes in patients with schizophrenia. The control group was given oral Pa Rossi Dean alone, and the observation group was given oral Morinda officinalis oligosaccharide capsule. The PANSS scores and serum biochemical indexes of the two groups before and after treatment were compared. Results The effective rate of the observation group was significantly higher than control group (P<0.05). The PANSS scores of the two groups after treatment were significantly lower (P<0.05), and the observation group was more obvious (P<0.05). After treatment, the levels of Cor, NGF and BDNF in serum of the two groups were significantly decreased (P<0.05), and the levels of serum 5-HT were significantly increased (P<0.05), especially in the observation group (P<0.05). The incidence of adverse reactions in the control group was 36.0%, which was 35.3% in the observation group, and there was no significant difference between the two groups. Conclusion Mengshi Guntan Wan combined with perperone has a significant therapeutic effect on schizophrenia. Its mechanism may be related to the reduction of serum Cor, NGF, BDNF levels and the increase of serum 5-HT levels.