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[摘要]
目的 研究谷氨酰胺联合生长抑素对急性胰腺炎患者肝功能的影响。方法 选择2015年1月-2017年12月安徽省第二人民医院急诊医学科收治的50例急性胰腺炎患者,随机分为对照组(n=25)和观察组(n=25)。对照组将6 mg生长抑素加入至500 mL生理盐水中进行静脉滴注,每天1次。观察组在对照组基础上联合静脉滴注谷氨酰胺,每次20 g,每天1次。两组均给药7 d。记录两组的机械通气时间、APACHE Ⅱ评分及住院时间,比较两组肝功能和血清炎性细胞因子水平。结果 观察组的有效率为92.00%,明显高于对照组的76.00%,差异有统计学意义(P<0.05)。观察组机械通气时间、APACHE Ⅱ评分及住院时间均明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)和丙氨酸氨基转移酶(ALT)均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组以上指标明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、超敏C反应蛋白(hs-CRP)均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组以上指标明显低于对照组,差异有统计学意义(P<0.05)。结论 谷氨酰胺联合生长抑素可以有效改善急性胰腺炎患者的肝功能,抑制炎症反应,效果明显优于单用生长抑素。
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[Abstract]
Objective To investigate the effect of somatostatin combined with glutamine on liver function in patients with acute pancreatitis.Methods Selected 50 cases of patients with acute pancreatitis who were treated in our hospital from January 2015 to December 2017,divided into the control group (n=25),and the observation group (n=25).The mechanical ventilation time,APACHE Ⅱ score and hospitalization time were recorded,and the liver function and serum inflammatory cytokine levels were compared before and after treatment.Results The effective rate of the observation group was 92.00%,which was significantly higher than that of the control group (76.00%,P<0.05).The duration of mechanical ventilation,APACHE Ⅱ score and hospitalization time in the observation group were significantly lower than those in the control group (P<0.05).After treatment,aspartate aminotransferase (AST),total bilirubin (TBIL) and alanine aminotransferase (ALT) in the two groups were significantly decreased,and there was significant difference before and after treatment in the same group (P<0.05);and the above indicators in the observation group were significantly lower than those in the control group (P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-alpha (TNF-alpha),interleukin-8(IL-8),and acute C-reactive protein (hs-CRP) in the two groups were significantly lower than those in the control group (P<0.05),and the above indexes in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Somatostatin combined with glutamine can effectively improve liver function and inhibit inflammatory reaction in patients with acute pancreatitis,and the effect is better than somatostatin alone.
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