目的 探讨麦角新碱联合卡前列素氨丁三醇预防和治疗宫缩乏力性产后出血的临床效果。方法 选取2015年5月-2018年5月入住河南科技大学第一附属医院的82例宫缩乏力性产后出血患者，随机分为观察组（n=41）和对照组（n=41）。对照组宫体注射卡前列素氨丁三醇250 μg；观察组在对照组基础上肌内注射麦角新碱0.2 mg。对比两组临床疗效、产后出血量、血红蛋白含量和凝血功能。结果 与对照组总有效率73.17%比较，观察组总有效率97.56%显著升高（P<0.05）。两组产后2 h出血量比较，差异无统计学意义。观察组产后2~24 h及产后24 h出血量均显著少于对照组（P<0.05），且血红蛋白含量显著高于对照组（P<0.05）。产后2 h两组纤维蛋白原（FIB）和D-二聚体（D-D）均显著低于产前（P<0.05）；且观察组凝血酶原时间（PT）、凝血酶时间（TT）均显著高于对照组（P<0.05），FIB和D-D均显著低于对照组（P<0.05）。结论 麦角新碱联合卡前列素氨丁三醇预防和治疗宫缩乏力性产后出血的效果显著，值得临床推广。

Objective To investigate the clinical effect of ergometrine combined with romethamine in the prevention and treatment of postpartum hemorrhage caused by uterine inertia.Methods 82 cases of postpartum hemorrhage caused by uterine inertia admitted to our hospital from May 2015 to May 2018 were randomly divided into observation group (ergometrine+romethamine,n=41) and control group (romethamine,n=41).The clinical efficacy,postpartum hemorrhage,hemoglobin content and coagulation function were compared between the two groups.Results The total effective rate of the observation group was 97.56%(40/41) higher than that of the control group[73.17%(30/41)](P<0.05).There was no significant difference in the amount of 2h bleeding between the two groups.The amount of bleeding in the observation group was significantly less than that in the control group (P<0.05),and the content of hemoglobin was significantly higher than that in the control group (P<0.05).FIB and D-D were significantly lower in both groups 2 hours after delivery (P<0.05),PT and TT in observation group were significantly higher than those in control group (P<0.05),FIB and D-D were significantly lower than those in control group (P<0.05).Conclusion Ergometrine combined with romethamine is effective in preventing and treating postpartum hemorrhage caused by uterine inertia,and is worthy of clinical promotion.