目的 探讨益生菌联合血必净注射液对急性胰腺炎患者的疗效及对降钙素原（PCT）、C反应蛋白（CRP）及D-二聚体的影响。方法 选取2015年12月-2017年12月郑州大学附属郑州中心医院收治的急性胰腺炎患者185例，随机将患者分为两组，对照组在常规治疗的基础上给予血必净注射液，观察组在对照组的基础上给予双歧杆菌乳杆菌三联活菌片，连续治疗7 d。比较两组治疗总有效率、临床症状和体征缓解时间及治疗前后PCT、CRP及血浆D-二聚体水平。结果 观察组总有效率为92.47%，显著高于对照组的81.52%（P<0.05）；观察组患者的腹痛腹胀缓解时间、恶心呕吐消失时间、肠鸣音恢复时间和血尿淀粉酶恢复时间均显著短于对照组（P<0.05）。治疗后，两组PCT、CRP及血浆D-二聚体水平均较治疗前显著下降（P<0.05），且观察组显著低于对照组（P<0.05）。结论 双歧杆菌乳杆菌三联活菌片联合血必净注射液可显著缩短急性胰腺炎患者临床症状及体征缓解时间，降低炎症反应，改善高凝状态，提高治疗的有效率。

Objective To investigate the effect of probiotics combined with Xuebijing Injection on PCT,CRP and D-D in patients with acute pancreatitis.Methods 185 cases of patients with acute pancreatitis were selected in our hospital from December 2015 to December 2017,and were divided into two groups.The control group were gave Xuebijing Injection on the basis of conventional treatment,the observation group were gave Bifidobacterium lactobacillus triple live bacteria tablet on the basis of the control group.Clinical therapeutic effects,remission time of clinical symptoms and signs,the levels of PCT,CRP and D-D before and after the treatment were compare between two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The time of abdominal pain and distension relieving,disappearance of nausea and vomiting,recovery of intestinal singing and hematuria amylase in the observation group were significantly shorter than those in the control group (P<0.05).There were no statistically significant differences in PCT,CRP and D-D levels between the two groups before treatment.After treatment,the above indicators were significantly decreased in both groups,and the observation group was significantly lower than the control group (P<0.05).Conclusion Bifidobacterium lactobacillus triple live bacillus tablets combined with Xuebijing Injection can significantly shorten the relief time of clinical symptoms and signs in patients with acute pancreatitis,reduce the inflammatory reaction,improve the hypercoagulation state,and improve the efficiency of treatment.

河南省科技攻关计划项目（2018020772）