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[摘要]
目的 研究酚妥拉明联合亚胺培南西司他丁治疗重症新生儿肺炎的疗效。方法 选择2015年1月-2017年12月驻马店市中心医院收治的108例重症新生儿肺炎患者,随机分为两组。对照组单独采用亚胺培南西司他丁治疗,每次0.5 g,每6 h给药1次;观察组在对照组基础上联合给予酚妥拉明0.2 mg/kg,每天给药2次。两组均治疗5 d。比较两组的症状改善情况、血清炎症因子和肺功能的改变情况。结果 与对照组有效率74.07%比较,观察组有效率88.89%明显提高,差异有统计学意义(P<0.05)。观察组的体温恢复正常时间、每天吸痰次数以及肺部啰音消失时间明显低于对照组,差异有统计学意义(P<0.05)。两组治疗后的血清C反应蛋白(CRP)、白介素-4(IL-4)以及白介素-6(IL-6)水平均明显降低,白介素-10(IL-10)水平明显升高,同组治疗前后比较差异均有统计学意义(P<0.05);且观察组明显优于对照组,组间差异有统计学意义(P<0.05)。两组治疗后的第一秒最大呼气量(FEV1)、用力肺活量(FVC)、用力呼气25%流速(MEF25)、最大呼气流速峰值(PEF)及用力呼气50%流速(MWV50)均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且观察组以上指标明显高于对照组,组间差异有统计学意义(P<0.05)。结论 酚妥拉明联合亚胺培南西司他丁治疗重症新生儿肺炎的效果较为确切,值得应用推广。
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[Abstract]
Objective To investigate the effect of phentolamine combined with imiminosinastatin in the treatment of severe neonatal pneumonia.Methods Selected 108 cases of patients with severe neonatal pneumonia who were treated in our hospital from January 2015 to December 2017,divided into two groups randomly.The control group was treated with imiminosinastatin and the observation group was given phentolamine.Symptom improvement,serum inflammatory factors and lung function were compared between the two groups.Results The effective rate of the observation group was significantly higher than control group (P< 0.05).The recovery time of body temperature,the frequency of sputum aspiration and the time of pulmonary rales disappeared in the observation group were significantly lower than those in the control group (P< 0.05).The average levels of serum CRP,IL-4 and IL-6 in the two groups were significantly decreased (P< 0.05),and the level of IL-10 increased significantly (P< 0.05),and the observation group was more significant (P< 0.05).FEV1,FVC,MEF25,PEF and MWV50 in the two groups were significantly increased (P< 0.05),and the observation group was more significant (P< 0.05).Conclusion Phentolamine combined with imipenem cilastatin in the treatment of severe neonatal pneumonia is more effective,worthy of application and promotion.
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