目的 研究冠心病患者治疗中阿托伐他汀联合曲美他嗪对心绞痛改善情况和血脂水平的影响。方法 选取2015年11月-2017年12月就诊的149例冠心病患者作为研究对象，按随机数字表法分为对照组（n=71）和观察组（n=78）。对照组患者口服曲美他嗪20 mg、3次/d，观察组在对照组基础上口服阿托伐他汀20 mg、1次/d，8 d为1个疗程。对比两组患者平板运动试验、丙二醛（MDA）和超氧化物歧化酶（SOD）水平、血脂水平和临床疗效。结果 治疗后研究组的诱发心绞痛发作时间和运动持续时间明显高于对照组，心电图ST段下移1 mm时间明显低于对照组（P<0.05）；两组治疗后ST段下移1 mm时间、诱发心绞痛发作时间和运动持续时间等平板运动试验项目均明显高于同组治疗前（P<0.05）。两组治疗后MDA和SOD水平与各自治疗前对比均有统计学差异（P<0.05）；治疗后观察组患者MDA水平明显低于对照组，SOD水平明显高于对照组（P<0.05）。两组治疗后血脂水平与同组治疗前比较均有统计学差异，且观察组患者血脂水平明显低于对照组（P<0.05）。对照组患者总有效率为67.61%，观察组患者总有效率为93.59%，两组比较有统计学差异（P<0.05）。结论 在冠心病治疗中，阿托伐他汀联合曲美他嗪可明显抑制氧化应激损伤，改善心电图平板试验、改善血脂代谢，提高疗效，值得临床推广。

Objective To research the influence of angina improvement and lipid levels of atorvastatin combined with trimetazidine in the treatment of coronary heart disease (CHD).Methods A total of 149 CHD patients from November 2015 to December 2017 were selected and randomly divided into two groups called control group (71 patients) and research group (78 patients),the control group was treated by trimetazidine,20 mg tid,while the research group were treated by trimetazidine combined with atorvastatin,the therapeutic method was 20 mg trimetazidine tid,combined with 20 mg atorvastatin qd.Compared with the plate motion test,MDA,SOD,lipid levels,and clinical efficacy of two groups.Results The trigger angina attack time and duration of movement after treatment of research group were much higher than control group,time of ST segment reduction 1 mm of research group after treatment was much lower than control group,and had statistical difference (P< 0.05);Moreover,the plate motion test indexes such as time of ST segment reduction 1 mm,trigger angina attack time and duration of movement of two groups were all much higher than before treatment respectively,and had statistical difference (P< 0.05).The MOD level of research group after treatment was much lower than control group,SOD level was much higher than control group,and had statistical difference (P< 0.05);Moreover,the MDA and SOD levels of two groups after treatment had statistical difference with before treatment respectively (P< 0.05).The lipid levels such as LDL,HDL-C,TG,TC of research group after treatment were much lower than control group,and had statistical difference (P< 0.05);Moreover,the LDL,HDL-C,TG,and TC of two groups after treatment had statistical difference with before treatment respectively (P< 0.05).The total effective rate of control group was 67.61%,total effective rate of research group was 93.59%,the total effective rate of two groups had statistical difference (P< 0.05).Conclusion In the treatment of CHD,trimetazidine combined with atorvastatin could significantly inhibit oxidative stress injury,improve the electrocadiogram tablet test,improve blood lipid metabolism,and improve the therapeutic effect of CHD,which is worthy of promotion.