[关键词]
[摘要]
药物转运体在中药及单体成分的体内吸收、分布和排泄过程中发挥着重要的作用。中药及单体对药物转运体的功能和表达可产生诱导或抑制作用,从而影响这些转运体底物的体内处置过程。随着中药药动学的发展,基于转运体介导的中药及单体体内处置研究越来越受到重视。该文对药物转运体介导的中药及单体药动学的研究进行综述。
[Key word]
[Abstract]
Drug transporters play an important role in the absorption, distribution and excretion of traditional Chinese medicine (TCM) and monomers in vivo. TCM and monomers can induce or inhibit the function and expression of drug transporters, thus affecting the disposal of substratesin vivo. With the development of pharmacokinetics of TCM, drug transporters mediated TCM and monomer disposal in vivohave been more and more reported. In this review, we reviewed the research on drug transporters mediated pharmacokinetics of TCM and monomers.
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