[关键词]
[摘要]
糖尿病肾病是糖尿病主要的慢性微血管并发症之一,也是引起终末期肾病最常见的原因。糖尿病肾病代谢组学通过研究内源性代谢物产生的变化性和规律性,寻找新的诊断指标,并为糖尿病肾病的早期诊断和机制研究提供了新思路。综述近十年来糖尿病肾病代谢组学的差异代谢物研究现状,并从差异代谢物的检出频次、样本分布、类别及生物学意义方面进行了深入分析,以期促进糖尿病肾病病理机制更广泛而深入的研究。
[Key word]
[Abstract]
Diabetic Kidney Disease is one of most common chronic microvascular complications of diabetes mellitus. It is the leading pathogency of end-stage of renal disease and the main death cause of diabetes mellitus. Metabolomics of diabetic kidney disease were to look for new detection targets and establish new identification technology by studying the regularity and characteristic of the endogenous small molecule metabolisms. we conducted a systematic search using the key terms of ‘metabolomics’ and ‘metabonomics’ with ‘diabetic kidney disease’. Finally we selected 39 articles. These researches help us to find more sensitive biomarkers to contribute to the diagnosis and therapeutic treatment of DKD at an early phase and provide some ideas for the research of DKD. This systematic review mainly summarized the current state of research on differential biomarkers of DKD and discussed the clinical relevance of metabolomics in the prediction, diagnosis and management of DKD.
[中图分类号]
[基金项目]
国家自然科学基金(81774014)