目的 探讨牛黄宁宫片联合齐拉西酮与奥氮平在精神分裂症治疗中的临床疗效。方法 选取2016年1月-2017年12月南阳市精神病医院71例精神分裂症患者为研究对象，根据硬币投掷法将受试者分为对照组35例和观察组36例，对照组给予齐拉西酮联合奥氮平治疗，观察组患者在对照组的基础上联合牛黄宁宫片治疗，两组均持续治疗6周。比较两组患者的临床疗效、治疗前后阳性和阴性综合征量表（PANSS）评分、临床总体印象-严重度量表（CGI-S）评分、患者的社会功能变化及不良反应发生率。结果 观察组患者治疗总有效率为88.89%，对照组患者治疗总有效率为62.86%，两组比较差异有统计学意义（P<0.05）。治疗前两组患者的PANSS评分、CGI-S评分及患者的社会功能比较无统计学差异，治疗后两组患者CGI-SI及PANSS评分较治疗前均显著降低（P<0.05），社会功能各指标评分较治疗前均显著升高（P<0.05）；且观察组优于对照组，两组比较差异有统计学意义（P<0.05）。观察组不良反应发生率为11.11%，对照组不良反应发生率为42.86%，两组比较差异有统计学意义（P<0.05）。结论 牛黄宁宫片联合齐拉西酮与奥氮平可有效改善患者的临床症状，提高治疗效果及患者的社会功能，减少不良反应，在精神分裂症治疗中具有重要临床意义。

Objective To explore clinical effect of Niuhuang Ninggong Table combined with ziprasidone and olanzapine in the treatment of schizophrenia.Methods 71 patients with schizophrenia were selected as the subjects from January 2016 to December 2017. According to the coin throwing method, all patients were divided into control group of 35 cases and study group of 36 cases. The control group were treated with ziprasidone and olanzapine, the experimental group on the basis of this combination of Niuhuang Ninggong Table. The clinical effect, the PANSS score and CGI-S score, the changes of social function before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The total effective rate in the experimental group were significant higher than in the control group (88.89% vs 62.86%) (P<0.05), there were no significant differences in the PANSS score, CGI-S score and social function between the control group before treatment. After treatment, the PANSS score and CGI-S score of the study group were significantly lower than before treatment, the social function significantly improve than before treatment, and the experimental group were obviously better than the control group, and there was significant difference (P<0.05). The incidence of adverse reactions in the experimental group were significant lower than in the control group (11.11% vs 42.86%) (P<0.05).Conclusion s Niuhuang Ninggong Table combined with ziprasidone and olanzapine in the treatment of schizophrenia can effectively improve clinical symptoms, increase social function and treatment efficacy, and reduce adverse reactions, has improtant value.