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[摘要]
目的 研究维生素D联合沙丁胺醇治疗小儿支气管哮喘的效果。方法 选择2014年1月-2016年12月郑州大学附属儿童医院的79例小儿支气管哮喘患儿,随机分为两组。对照组(n=40)采用压缩雾化吸入沙丁胺醇治疗,观察组(n=39)在对照组基础上联合口服维生素D。治疗90 d,比较两组的治疗有效率、喘憋症状消失时间、咳嗽缓解时间、肺部哮鸣音消失时间和肺部湿啰音消失时间。结果 观察组患儿的有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组的血清25-羟维生素D3水平均明显升高,嗜酸细胞阳离子蛋白(ECP)及血清特异性IgE水平均明显降低,同组治疗前后比较差异均有统计学意义(P<0.05);且观察组更为明显,组间比较差异有统计学意义(P<0.05)。观察组的喘憋症状消失时间、咳嗽缓解时间、肺部哮鸣音消失时间和肺部湿啰音消失时间均明显短于对照组,差异有统计学意义(P<0.05)。结论 维生素D联合沙丁胺醇对小儿支气管哮喘具有较为满意的治疗效果,可以有效改善患儿的临床症状,其作用机制可能与提高血清25-羟维生素D3水平,降低ECP和Ig E水平有关。
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[Abstract]
Objective To study the effect of Effect of vitamin D combined with salbutamol on children with bronchial asthma. Methods Selected 79cases of patients with bronchial asthma who were treated in our hospital from January 2014 to December 2016, divided into two groups randomly. The control group was treated with aerosol inhalation of salbutamol, and the observation group was given vitamin D. The time of wheezing and disappearance of symptoms, the time of cough relieving, the time of disappearing of pulmonary wheezing and the time of pulmonary wet rales disappeared were compared between the two groups.Results The effective rate of the observation group was significantly higher than control group (P<0.05). The levels of serum 25-hydroxyvitamin D3 in the two groups increased significantly (P<0.05), while the ECP and Ig E water decreased significantly (P<0.05), and the observation group was more obvious (P<0.05). The disappearance time of asthmatic symptoms, the time of cough remission, the disappearance time of lung wheezing sound and the loss of lung rale were significantly shorter in the observation group than in the control group (P<0.05).Conclusion Vitamin D combined with salbutamol has a more satisfactory therapeutic effect on bronchial asthma in children. It can effectively improve the clinical symptoms of children. Its mechanism may be related to improving the level of serum 25-hydroxyvitamin D3 and reducing the level of ECP and Ig E.
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