目的 用中红外光谱技术对6家企业生产的黄柏、茯苓及熟地黄3种配方颗粒进行质量考察，分析了不同企业配方颗粒的一致性。方法 以峰位、峰形、相对峰强度或主要标准峰个数等为考察指标，对不同企业生产的同一品种的配方颗粒与标准药材及自制提取物的谱图进行对比，分析三者之间的差异（相似度）。结果 6家企业的黄柏配方颗粒在1 604、1 507 cm^-1处特征峰的相对峰高的变化不同，其原药材质量可能存在差异；茯苓配方颗粒因采用辅料种类不一，中红外光谱图差异明显；熟地黄配方颗粒因原药材投料比不同，随着辅料含量的增加，与熟地黄提取物的相关系数降低。结论 中红外光谱具有操作简单、快速、专属性强、不需要对样品进行分离等优点，尤其是揭示不同企业的同一种配方颗粒因采用原药材的品质、辅料不同等因素所造成质量差异，因此，中红外光谱技术为保证配方颗粒的均一性提供了客观的分析手段和数据支撑。

Objective The quality investigation on Phellodendron, Poria Cocos and Rehmannia glutinosa formula granules by midinfrared spectroscopy, which analyzes different enterprises of formula particles of consistency. Methods In the peak position, peak shape, relative peak intensity or the number of the main standard peaks as the investigation index, the spectrogram of formula granules from the six enterprises in the same variety were compared with rude drug and self-made extract, analyzed the differences between the three of them(similarity). Results The differences in the relative absorption peak heights at 1 604 cm^-1 and 1 507 cm^-1 are different, and the quality of the original medicinal materials may be different. The types of accessories of Poria formula particles were different, the mid-infrared spectroscopy of them were significantly different. Rehmannia glutinosa formula granule because of the different dosing ratio of raw materials, the correlation coefficient for Rehmannia glutinosa extract was decreased with the increase in the amount of excipients. Conclusions Mid-infrared spectroscopy has the advantages of simple operation, rapidity, high specificity and no separation of samples, especially to revealed the quality difference of the same formula particles from different enterprises was because of the quality of raw materials, processing methods, extraction technology, different accessories and other factors, in order to ensure the consistency and stability of granule, it provides an objective analysis method and data support.

天津市科技计划项目（16ZXZYNC00060，15YDLJSY00100）