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[摘要]
目的 比较乌拉地尔及硝普钠对高血压脑出血患者急性期降压作用及预后的影响。方法 将高血压脑出血患者根据用药情况分为乌拉地尔组及硝普钠组。硝普钠组患者予以注射用硝普钠治疗,治疗初始剂量为0.5~1.0 μg/(kg·min);乌拉地尔组患者予以乌拉地尔注射液治疗。比较两组用药后血压变化、心率变化、血肿大小变化及神经功能评分的差异。结果 两组患者在分别用药10、20、30、60、120 min后,使用乌拉地尔组患者平均收缩压及平均舒张压高于使用硝普钠组患者,组间差异具有统计学意义(P<0.05),在分别用药240 min后,两组患者的平均收缩压及平均舒张压差异无统计学意义。在分别用药10、20、30、60、120、240 min后,乌拉地尔组患者的平均心率低于硝普钠组患者的平均心率,组间差异具有统计学意义(P<0.05)。在分别用药24、72 h后,两组患者的血肿大小差异无统计学意义。1个月后,两组患者的神经功能评分具有显著差异(P<0.05)。结论 乌拉地尔能有效控制高血压脑出血患者急性期血压,且其神经功能保护作用较硝普钠显著。
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[Abstract]
Objective To compare the effects of urapidil and sodium nitroprusside on blood pressure and prognosis in patients with hypertensive intracerebral hemorrhage.Methods After 10, 20, 30, 60 and 120 minutes, the systolic blood pressure and diastolic blood pressure of patients in urapidil group were lower than those in sodium nitroprusside group (P<0.05). After 240 minutes, two groups's diastolic blood pressure were not significantly different. After 10, 20, 30, 60, 120 and 240 minutes, the heart rate of patients in urapidil group were lower than that in sodium nitroprusside group, the difference was statistically significant (P<0.05). There was no significant difference in the size of hematoma between the two groups. After 1 month, there were significant differences in neurological scores between the two groups (P<0.05).Conclusion Urapidil can effectively control blood pressure in patients with hypertensive intracerebral hemorrhage, and its long-term neuroprotective effect than sodium nitroprusside significantly.
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