目的 探讨醋酸亮丙瑞林微球联合炔雌醇环丙孕酮片对子宫内膜异位症患者疗效及复发率的影响。方法 选择汉中市中心医院2014年1月—2016年12月收治的83例子宫内膜异位症患者，根据随机数字表法，分为观察组（42例）与对照组（41例），对照组给予炔雌醇环丙孕酮片治疗，观察组在对照组基础给予醋酸亮丙瑞林微球治疗。两组均治疗3个月。观察对比两组临床疗效、治疗后1年内的复发率、治疗前后的性激素水平、Kupperman评分、主观症状评分及治疗期间的不良反应。结果 两组临床疗效对比无统计学意义，但观察组复发率明显低于对照组，差异有统计学意义（P<0.05）。治疗前，两组的促卵泡生成激素、促黄体生成激素、雌二醇水平、Kupperman评分及主观症状评分对比无统计学意义；治疗后，两组以上指标均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组明显低于对照组，差异有统计学意义（P<0.05）。两组不良反应对比无统计学意义。结论 醋酸亮丙瑞林微球联合炔雌醇环丙孕酮片治疗子宫内膜异位症疗效显著，可降低术后复发率、雌激素，改善临床症状，安全性较好。

Objective To investigate the efficacy and recurrence rate of leuprolide microspheres combined with Diane-35 in patients with endometriosis. Methods 83 cases with endometriosis from Jan. 2014 to Dec. 2016 in our hospital were chosen, who were divided into the observation group (42 cases) and control group (41 cases), the control group were given Diane-35, the observation group were given leuprolide microspheres on the base of control group, the efficacy, recurrence rate after treatment for 1 year, the sex hormone levels before and after treatment, the Kupperman score, the subjective symptom score and adverse reactions in treatment of two groups were compared. Results The efficacy of two groups had no significant different, the recurrence rate of observation group was lower than control group (P<0.05), the follicle growth hormone, luteinizing hormone and estradiol level, the Kupperman score, the subjective symptom score of two groups had no significant difference before treatment (P<0.05), the indexes after treatment of two groups were lower than before treatment, while the observation group were lower than control group (P<0.05). The adverse reactions of two groups had no significant. Conclusion Leuprolide microspheres combined with Diane-35 had significant efficacy in treatment of endometriosis, which could decrease the recurrence rate, estrogen level, improve the clinical symptoms and had great safety.