目的 探讨依那普利联合硝苯地平缓释片治疗原发性高血压的疗效及对血清氧化应激指标的影响。方法 以2014年3月—2017年5月延安市人民医院诊治的78例原发性高血压患者为研究对象。根据随机数字表法分为对照组和观察组各39例。所有患者入组后给予高血压综合治疗，对照组患者口服硝苯地平缓释片，观察组在此基础上口服依那普利片。分析对比两组的治疗总有效率和不良反应发生率，治疗前后的血压和氧化应激指标水平及氧化应激指标水平与收缩压（SBP）水平之间的关系。结果 治疗后两组的SBP和舒张压（DBP）均低于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后观察组的SBP和DBP均低于对照组，差异有统计学意义（P<0.05）。观察组的总有效率（94.87%）高于对照组（76.92%），差异有统计学意义（P<0.05）。治疗后两组的超氧化物歧化酶（SOD）高于且丙二醛（MDA）和晚期蛋白氧化产物（AOPP）低于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后观察组的SOD高于且MDA和AOPP低于对照组，差异有统计学意义（P<0.05）。SOD水平与SBP水平呈负相关且MDA和AOPP水平与SBP水平均呈正相关（P<0.05）。两组的不良反应发生率分别为12.82%和15.38%，差异无统计学意义。结论 依那普利联合硝苯地平缓释片治疗原发性高血压疗效确切，较安全，并可改善氧化应激状态。
Objective To discuss the curative effect of nifedipine slow release tablets combined with enalaprilat in treatment withprimary hypertension and its effect on serum oxidative stress index.Methods A total of 78 primary hypertension patients treated in our hospital from March 2014 to May 2017 were studied and were divided into control group and observation group according to the random number table method. All patients were treated with hypertensive therapy, and control group was treated with oral nifedipine slow release tablets. On that basis, observation group was given oral enalaprilat. The total effective rate and incidence of adverse reactions, blood pressure, oxidative stress index and the relationship between SBP and oxidative stress index of two groups were analyzed.Results Both SBP and DBP level of two groups after treatment were lower than those before treatment (P<0.05), and SBP and DBP level of observation group were lower than those of control group (P<0.05). The total effective rate of observation group (94.87%) was higher than that of control group (76.92%) (P<0.05). After treatment, SOD level of two groups was higher and MDA and AOPP levels were lower than those before treatment (P<0.05), SOD level of observation group was higher and MDA and AOPP levels were lower than those of control group (P<0.05). SOD level was negatively correlated with SBP level and MDA and AOPP levels were positively correlated with SBP level (P<0.05). The incidence rate of adverse reactions of both groups was 12.82% and 15.38%, respectively, and the difference was not statistically significant.Conclusion The curative effect of nifedipine slow release tablets combined with enalaprilat in treatment with primary hypertensionis effective, safe and can improve the state of oxidative stress.