目的 利用CiteSpace对2005—2025年质谱成像技术在药物有效性、安全性、组织分布等药物评价研究领域的文献进行计量与可视化，深入探讨质谱成像技术在药物评价研究的研究现状、热点和未来发展趋势。方法 以中国学术期刊全文数据库（CNKI）、Web of Science中英文数据库收录的质谱成像技术应用于药物评价研究的相关文献为研究对象，采用CiteSpace 6.4.R1软件进行作者、机构、国家分析及关键词的共现、聚类、突现分析。结果 共检索到880篇文献，文献年发表量总体逐年上升，国内主要作者有再帕尔·阿不力孜、贺玖明、蔡宗苇等，主要研究机构有中央民族大学、中国医学科学院药物研究所、香港浸会大学等。关键词分析结果可知，质谱成像技术在药物评价研究中主要用于药物递送、药物定量分析、药物空间分布、生物合成途径及药物安全性评价等。结论 系统分析了2005—2025年质谱成像技术在药物评价研究领域的相关文献，总结了目前全球质谱成像技术在该领域的研究现状及发展趋势，为药物评价研究的未来发展方向提供指导。

Objective To conduct a bibliometric and visual analysis of literature from 2005 to 2025 on the application of mass spectrometry imaging (MSI) in drug evaluation research, including drug efficacy, safety, and tissue distribution, using CiteSpace, and to explore the current status, hotspots, and future trends of MSI in this field. Methods Literature related to the application of MSI in drug evaluation research was retrieved from Chinese and English databases, including China National Knowledge Infrastructure (CNKI) and Web of Science. CiteSpace 6.4.R1 software was used to analyze authors, institutions, countries, as well as keyword co-occurrence, clustering, and burst detection. Results A total of 880 articles were retrieved, with an overall annual increase in publications. Key authors in China include Zeping Abliz, Jiuming He, Zongwei Cai, etc. Major research institutions include the Institute of Materia Medica, Chinese Academy of Medical Sciences, and Hong Kong Baptist University. Keyword analysis revealed that MSI is primarily applied in drug delivery, quantitative drug analysis, spatial drug distribution, biosynthetic pathways, and drug safety evaluation. Conclusion This study systematically analyzed literature from 2005 to 2025 on the application of MSI in drug evaluation research, summarized the global research status and development trends in this field, and provided guidance for future research directions in drug evaluation.

R917

国家自然科学基金青年项目（82404894）；山西省科技厅基础研究项目（202303021212128）；山西省卫生健康委中医药科研项目（2024ZYYC076）；山西医科大学省级博士基金项目（SD2304）；山西医科大学校级博士启动基金项目（XD2247）