灯盏花为菊科飞蓬属植物短葶飞蓬Erigeron breviscapus的干燥全草，苗药名“锐改外”，又名灯盏细辛，具有活血通络止痛、祛风散寒功效。其主要化学成分为黄酮类、咖啡酰奎宁酸类及挥发油等；现代药理研究表明其具有心脑血管保护、神经保护、抗炎、抗氧化、抗肿瘤等多种药理作用。系统综述灯盏花化学成分、药理作用、临床应用及安全性研究进展，并基于中药质量标志物（Q-Marker）的传递与溯源、特有性、有效性和可测性原则，对其潜在Q-Marker进行预测分析。综合分析预测野黄芩苷、灯盏花甲素、咖啡酰奎宁酸类成分可作为灯盏花Q-Marker候选成分，以期为灯盏花质量评价体系构建及质量标准完善提供参考。

Erigeron breviscapus (Vant.), a plant of the genus Erigeron in the family Asteraceae, is known as “Rui Gai Wai” in Miao medicine and also called “Dengzhan Xixin” Its dried whole herb has traditional uses for promoting blood circulation, relieving pain, dispelling wind-cold, and unblocking meridians. The main chemical constituents include flavonoids, caffeoylquinic acids, and volatile oils. Modern pharmacological studies have demonstrated its diverse effects, such as cardiovascular and cerebrovascular protection, neuroprotection, anti-inflammation, antioxidant activity, and antitumor properties. This review systematically summarizes recent advances in research on the chemical composition, pharmacological activities, clinical applications, and safety of E. breviscapus. Based on the principles of quality markers (Q-Marker) in traditional Chinese medicine—transmissibility and traceability, uniqueness, efficacy, and measurability—the potential Q-Markers of E. breviscapus were predicted and analyzed. Comprehensive analysis suggests that scutellarin, apigenin-7-O-glucuronide, and caffeoylquinic acid derivatives could serve as candidate Q-Markers for E. breviscapus, providing valuable insights for establishing a quality evaluation system and improving quality standards.

R285.5;R284

国家自然科学基金地区项目（82460727）