目的 运用文献计量学方法系统梳理白鲜皮研究现状、热点及趋势，为其物质基础、药理机制、安全性评价与临床应用提供参考。方法 检索2000年1月1日—2025年12月31日中国学术期刊全文数据库（CNKI）、万方数据知识服务平台（Wanfang）、维普生物医学数据库（VIP）及Web of Science核心合集（WoSCC）收录的白鲜皮相关中、英文文献；经NoteExpress去重与筛选后，采用Excel、CiteSpace、VOSviewer软件，从发文趋势、国家、机构、作者及关键词等维度进行可视化分析。结果 共纳入中文文献1 198篇，英文文献164篇。中文文献长期占主导，但近年发文量有所下降；英文文献逐年递增，反映白鲜皮相关研究的国际关注度逐步提高。中国为主要发文国家，研究力量主要集中于亚洲地区。中文文献以黑龙江中医药大学、成都中医药大学、北京中医药大学等为主要发文机构，英文文献以China Pharmaceutical University、Peking Union Medical College等为主要发文机构。中文文献以刘树民、卢芳等发文量较为突出，英文文献Kim Hyungwoo发文量最高。中文文献研究多聚焦白鲜皮治疗银屑病、湿疹、荨麻疹、特应性皮炎等皮肤炎症性疾病的临床应用、辨证论治及用药规律；英文文献研究更侧重白鲜碱、梣酮、黄柏酮、柠檬苦素类等活性成分、抗炎免疫机制及肝毒性等安全风险评价。结论 白鲜皮相关研究已由临床经验总结，逐步拓展至活性成分解析、药理机制阐释及安全性评价等方向。后续研究可重点围绕白鲜皮治疗皮肤炎症性疾病的药效机制、活性成分解析与质量控制、肝毒性机制、机器学习辅助毒性风险预测及炮制配伍减毒策略深入开展。

Objective To analyze the current research status, hotspots, and trends of Dictamni Cortex using bibliometric methods, and to provide references for studies on its material basis, pharmacological mechanisms, safety evaluation, and clinical application. Methods Chinese and English publications related to Dictamni Cortex published from January 1, 2000 to December 31, 2025 were retrieved from the China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Web of Science Core Collection (WoSCC). After deduplication and screening using NoteExpress, Excel, CiteSpace, and VOSviewer were used to conduct visual analyses from multiple dimensions, including publication trends, countries, institutions, authors, and keywords. Results A total of 1 198 Chinese publications and 164 English publications were included. Chinese publications have long predominated in this field, although the annual publication output has declined in recent years; in contrast, English publications showed an upward trend, indicating gradually increasing international attention. China was the main contributing country, and research output was mainly concentrated in Asia. In Chinese publications, Heilongjiang University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, and Beijing University of Chinese Medicine were the major contributing institutions, whereas China Pharmaceutical University and Peking Union Medical College were the main contributing institutions in English publications. Liu Shumin and Lu Fang showed prominent publication outputs in Chinese publications, while Kim Hyungwoo had the highest publication output in English publications. Chinese studies mainly focused on the clinical application, syndrome differentiation-based treatment, and medication patterns of Dictamni Cortex in inflammatory skin diseases, such as psoriasis, eczema, urticaria, and atopic dermatitis. English studies placed greater emphasis on bioactive constituents, including dictamnine, fraxinellone, obacunone, and limonoids, as well as anti-inflammatory and immunomodulatory mechanisms and safety issues such as hepatotoxicity. Conclusion Research on Dictamni Cortex has gradually expanded from the summarization of clinical experience to bioactive constituent analysis, pharmacological mechanism elucidation, and safety evaluation. Future studies should further focus on the pharmacodynamic mechanisms of Dictamni Cortex in inflammatory skin diseases, bioactive constituent analysis and quality control, mechanisms of hepatotoxicity, machine-learning-based prediction of hepatotoxicity risk, and detoxification through processing and herbal compatibility.

R285.5

上海市2023年度“科技创新行动计划”（23Y31920300）；上药-上中医联合研究院（E4-H200210399）；上海市申康课题（SHDC2025CCS013）；上海市中医药管理局（2025CXGZS-14）；江西省卫生健康委科技计划（SKJP1220243261）；上海申康医院发展中心诊疗技术推广及优化管理项目（SHDC22025306）；宋瑜名中医工作室经费（上海龙华医院江西医院）；江西省中医药管理局（2025020707）