目的 运用文献计量学方法梳理槲皮素近10年的研究热点并分析发展趋势，为槲皮素的开发与临床应用提供参考。方法 以中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、维普生物医学数据库（VIP）及Web of Science核心合集为数据来源，检索近10年槲皮素相关中、英文文献，经NoteExpress查重后，利用Excel、Origin、CiteSpace、VOSviewer软件对中、英文文献的发文量、国家、机构、作者合作、关键词共现等进行可视化分析。结果 共纳入有效中文文献2 129篇，英文文献6 252篇。近10年槲皮素中、英文文献发文量均呈稳步上升趋势。全球共105个国家对槲皮素进行了研究，其中中国学术产出总量最高。国内外核心研究机构分别为广州中医药大学和沙特国王大学；中、英文发文量最多的作者分别是翟广玉、Yao Ping（姚平），其中翟广玉主要围绕槲皮素及其衍生物的生物活性开展研究，姚平团队重点探究槲皮素经铁死亡、线粒体等通路对肝脂肪变性、心肌损伤、动脉粥样硬化的作用机制，沈丽霞、姚平已分别形成稳定的核心研究团队。关键词分析显示，中文研究以网络药理学、分子对接为热点，英文研究聚焦黄酮类化合物、氧化应激等方向，涵盖成分鉴定、细胞凋亡等细胞生物学机制；整体研究热点由早期的化学成分与基础活性研究，逐步转向槲皮素及其纳米载体的体内外药理实验研究。结论 近10年槲皮素相关研究整体处于持续拓展、稳步上升的发展阶段，核心研究热点集中于槲皮素基于氧化应激、细胞凋亡通路发挥的多维度药理作用。未来该领域需强化国际化、团队化协同研究，重点推进槲皮素的临床研究与成果转化。

Objective To identify research hotspots and analyze the development trends of quercetin over the past decade using bibliometric methods, providing references for its development and clinical application. Methods Data were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and Web of Science Core Collection to retrieve English and Chinese literature on quercetin published in the last 10 years. After duplicate removal via NoteExpress, visualization analyses of publication volume, countries, institutions, author collaborations, and keyword co-occurrence were conducted using Excel, Origin, CiteSpace, and VOSviewer. Results A total of 2 129 valid Chinese articles and 6 252 English articles were included. The number of publications on quercetin has shown a steady upward trend in both Chinese and English literatures over the past decade. Research on quercetin was conducted by 105 countries worldwide, with China leading in total academic output. The core research institutions were Guangzhou University of Chinese Medicine and King Saud University. The authors with the highest number of publications were Zhai Guangyu and Yao Ping, respectively. Zhai’s team primarily focused on the biological activities of quercetin and its derivatives, while Yao’s group investigated the mechanisms of quercetin in liver steatosis, myocardial injury, and atherosclerosis through pathways such as ferroptosis and mitochondrial dysfunction. Shen Lixia and Yao Ping have formed a stable core research team. Keywords analysis revealed that Chinese studies emphasized network pharmacology and molecular docking, whereas English studies concentrated on flavonoids and oxidative stress, covering aspects such as compound identification and cellular mechanisms including apoptosis. Overall, research hotspots have gradually shifted from early investigations into chemical constituents and basic bioactivities to current focus on in vitro and in vivo pharmacological studies involving quercetin and its nano-carriers. Conclusion Over the past decade, quercetin-related research has been continuously expanding and steadily advancing, with key focuses on its multidimensional pharmacological effects mediated through oxidative stress and apoptosis pathways. Future research should strengthen international collaboration and teambased efforts, prioritizing clinical trials and translation of quercetin into practical applications.

R285.5

国家自然科学基金资助项目（82574989）；国家中医药管理局科技局科技共建项目（GZY-KJS-SD-2024-097）；山东省自然科学基金面上项目（ZR2024MH009）；济南市临床医学科技创新计划（202328072）；山东省自然科学基金创新发展联合基金项目（ZR2023LZL009）