目的 观察清咳平喘颗粒治疗轻、中度支气管哮喘（简称哮喘）急性发作期（热哮证）患者的临床疗效。方法 选取2023年8月—2024年12月就诊于昆山市中医医院门诊及病房的轻、中度哮喘急性发作期患者80例，按照1∶ 1原则随机分为观察组和对照组，每组各40例。对照组采取化学药治疗；观察组在对照组治疗基础上联合清咳平喘颗粒治疗，疗程均为5 d。以临床总有效率、治疗前后中医证候积分、体征分级量化表、用力呼气流量峰值（PEF）、临床症状起效时间、临床症状消失比例为疗效指标。结果 临床疗效结果显示，药物干预后，观察组总有效率为97.50%，优于对照组的总有效率87.50%，差异有统计学意义（P＜0.05）；治疗后，与对照组比较，观察组中医证候积分、体征分级量化表（喘息、咳嗽、哮鸣音）积分在第3、5天显著降低（P＜0.05）；治疗后，与对照组相比，观察组在治疗5 d后的PEF显著升高（P＜0.05），且PEF改善率大于对照组（P＜0.05）；治疗后，与对照组相比，观察组在治疗后的临床症状（喘息、哮鸣音、咳嗽）起效时间缩短（P＜0.05），临床症状消失率升高（P＜0.05）。结论 清咳平喘颗粒有助于改善轻、中度支气管哮喘急性发作期（热哮证）患者的中医证候积分、体征分级量化表积分、PEF，缩短临床症状起效时间和提高临床症状消失率，治疗效果明显，且药物安全，推荐临床应用。

Objective To observe the clinical efficacy of Qingke Pingchuan Granules in the treatment of patients with mild to moderate bronchial asthma (hot asthma syndrome) during the acute attack period. Methods A total of 80 patients with mild to moderate bronchial asthma in the acute attack period who visited the outpatient department and inpatient ward of Kunshan Hospital of Traditional Chinese Medicine from August 2023 to December 2024 were selected and randomly divided into the observation group and the control group at a ratio of 1:1, with 40 cases in each group. The control group was treated with western medicine, while the observation group was treated with Qingke Pingchuan Granules in addition to the treatment of the control group. After 5 d of treatment, the clinical efficacy, safety, TCM syndrome scores, symptom grading quantification table (wheezing, cough, wheezing sound), peak expiratory flow (PEF), onset time of clinical symptoms (wheezing, wheezing sound, cough), and the proportion of clinical symptom relief/disappearance were observed and compared between the two groups. Results The clinical efficacy results showed that after drug intervention, the total effective rate of the treatment group was 97.50%, which was significantly higher than that of the control group (87.50%), with a statistically significant difference (P<0.05). After treatment, compared with the control group, the TCM syndrome scores and symptom grading quantification table (wheezing, cough, wheezing sound) scores of the observation group were significantly reduced on the 3rd and 5th days (P<0.05). After treatment, compared with the control group, the PEF of the observation group was significantly increased on the 5th day (P<0.05), and the improvement rate of PEF was greater than that of the control group (P<0.05). After treatment, compared with the control group, the onset time of clinical symptoms in the observation group was reduced (P<0.05), and the disappearance rate of clinical symptoms was increased (P<0.05). Conclusion Qingke Pingchuan Granules can improve the TCM syndrome scores, symptom grading quantification table scores, and PEF of patients with mild to moderate bronchial asthma during the acute attack period (hot asthma syndrome), shorten the onset time of clinical symptoms, and increase the disappearance rate of clinical symptoms. The treatment effect is obvious, and the drug is safe. It is recommended for clinical application.

R974