当归六黄汤源自“金元四大家”之一李东垣所著的《兰室秘藏》，由当归、生地黄、熟地黄、黄芩、黄连、黄柏和黄芪7味药组成。该方以滋阴泻火、固表止汗为核心功效，为治疗阴虚火旺型盗汗的代表方剂，临床常用于糖尿病、围绝经期综合征、甲状腺功能亢进症等虚热内扰相关病症。系统梳理其历史源流、配伍规律、化学成分、药理作用及临床研究，为经典名方当归六黄汤的现代研究提供科学依据，推进其转化应用，实现中医药承古拓新。

Danggui Liuhuang Decoction, originally documented in Secret Book of Orchid Chamber by Li Dongyuan — one of the “Four Great Masters of the Jin-Yuan Era”.This formula is composed of seven medicinal ingredients: Angelicae Sinensis Radix, Rehmanniae Radix, Rehmanniae Radix Praeparata, Scutellariae Radix, Coptidis Rhizoma, Phellodendri Chinensis Cortex, and Astragali Radix. This formula is characterized by its core functions of nourishing yin to reduce fire and consolidating the exterior to check sweating. It is considered the first-line therapeutic option for treating night sweating attributable to yin deficiency with effulgent fire.It is often used clinically for diabetes, perimenopause syndrome, hyperthyroidism and other diseases related to internal disturbance of deficiency heat. This paper systematically combs its historical origin, compatibility law, chemical composition, pharmacological action and clinical research, provides a scientific basis for modern research on the classic formula Danggui Liuhuang Decoction, promotes its transformation and application, and realizes the inheritance of ancient Chinese medicine and innovation.

R285.5

2021年佛山市社会领域科技攻关专项(2120001007987)