目的 基于CiteSpace对靶向过氧化物酶体增殖物激活受体γ(PPAR-γ)抗动脉粥样硬化（AS）的中文及英文文献进行文献计量学及可视化分析，探讨PPAR-γ抗AS的研究现状及前沿趋势，为基础研究与临床转化提供科学依据和可行性建议。方法 以中国学术期刊全文数据库（CNKI）、万方数据知识服务平台（Wanfang data）、维普中文科技期刊数据库（VIP）作为中文文献检索平台，英文文献以Web of Science(WOS)为检索平台，时间跨度为建库至2024年12月31日。应用CiteSpace 6.4.1版对文献进行作者合作网络、机构共现及关键词共现聚类分析，通过对数似然比（LLR）算法提取聚类标签，结合突现检测揭示研究热点演化轨迹。结果 共纳入286篇中文文献及792篇英文文献。可视化分析结果显示，中、英文文献研究领域产出均呈现初期增长而后进入波动性回调阶段的演变规律。作者协作网络特征显示，研究者间已建立基础性合作关联，中文文献研究以本土学者为主导，机构合作多限于同地域的医科院校及其附属医院，跨地域协作网络尚未成熟，跨国合作较少。关键词共现分析表明PPAR-γ在国际研究中关注度较高。中文关键词聚类分析表明中文文献凸显中西医协同治疗模式，聚焦中医病机理论。英文关键词聚类展示了分子机制的系统解析，如脂代谢、胰岛素抵抗、氧化应激。结论 靶向PPAR-γ抗AS研究已形成机制探索-疾病关联-药物开发的研究体系，未来应着重通过多组学技术解析其调控网络，开发组织选择性激动剂，并加强基于系统生物学的中药复方作用机制研究，聚焦多学科交叉新方向。

Objective To conduct a bibliometric and visual analysis of Chinese and English literature on “PPAR-γ against atherosclerosis” using CiteSpace, exploring the current research landscape and frontier trends, thereby providing a scientific basis and feasible suggestions for basic research and clinical translation. Methods The Chinese literature was retrieved from the China National Knowledge Infrastructure(CNKI), Wanfang Data Knowledge Service Platform, and VIP Chinese Sci-Tech Journal Database(VIP). The English literature was sourced from the Web of Science(WOS) core collection. The publication timeframe spanned from the inception of each database to December 2024. CiteSpace(version 6.4.1) was employed to perform analyses of author collaboration networks, institutional co-occurrence, and keyword co-occurrence/clustering. The log-likelihood ratio(LLR) algorithm was used to extract cluster labels, and burst detection was applied to reveal the evolution of research hotspots. Results A total of 286 Chinese and 792 English publications were included. Visual analysis revealed a similar publication trend in both language domains: Initial growth followed by a phase of fluctuating adjustment. Author collaboration networks indicated the establishment of foundational cooperative relationships among researchers. Chinese research was predominantly led by domestic scholars, with institutional collaborations largely confined to medical universities and their affiliated hospitals within the same region; Cross-regional collaborative networks were not yet mature, and international collaborations were limited. Keyword co-occurrence analysis indicated a high level of international research interest in PPAR-γ. Chinese keyword clustering highlighted a model integrating traditional Chinese medicine(TCM) and western medicine, focusing on TCM pathogenesis theory. English keyword clustering demonstrated a systematic exploration of molecular mechanisms, such as lipid metabolism, insulin resistance, and oxidative stress. Conclusion Research on PPAR-γ against atherosclerosis has evolved into a system encompassing mechanism exploration, disease association, and drug development. Future efforts should focus on deciphering its regulatory networks using multi-omics technologies, developing tissue-selective agonists, strengthening research into the mechanisms of complex TCM formulations based on systems biology, and concentrating on new interdisciplinary directions.

R972

国家自然科学基金面上项目(82274488,81874446)