目的 对近20年柚皮苷相关研究的现状及热点进行可视化分析，为该领域后续研究的开展及理论体系的完善提供参考依据。方法 采用高级检索策略，分别在中国学术期刊全文数据库（CNKI）、维普数据库（VIP）、万方数据库（Wanfang）及Web of Science(WOS)、PubMed、Scopus数据库中，系统筛选柚皮苷相关中、英文文献；运用CiteSpace 6.4.R1软件对筛选后的文献进行可视化分析，分析内容涵盖发文量变化趋势、作者/机构/国家合作网络、关键词时间线、关键词聚类、关键词突现、关键词共现及高被引文献等核心维度。结果 共检索获得柚皮苷中文文献2 135篇、英文文献2 151篇；中文文献发文量呈现“先上升后平稳”的发展态势，英文文献发文量则持续保持上升趋势。英文文献发文量占比位居前列的国家为中国、印度、美国，且排名前10的国家间存在一定的合作关联；英文文献研究机构间合作紧密，而中文文献发文机构间合作相对松散。中、英文文献核心研究团队包括陈丹团队、苏薇薇团队及Ahmed、Osama M团队。全球范围内柚皮苷相关研究主要聚焦于提取工艺、质量控制、药理活性及作用机制等核心方向。结论 近20年来柚皮苷研究热度始终居高不下，研究重点集中于其抗肿瘤、抗炎、抗氧化、抗骨质疏松及促成骨作用、代谢调节等药理活性，以及质量评价相关研究，为后续研究的深入开展奠定了基础。

Objective To conduct a visual analysis of the current status and hotspots of naringin-related research over the past 20 years, providing a reference basis for the subsequent research and theoretical system improvement in this field. Methods An advanced search strategy was adopted to systematically screen Chinese and English literature related to naringin from the China National Knowledge Infrastructure(CNKI), VIP Database, Wanfang Database, Web of Science(WOS), PubMed, and Scopus. CiteSpace 6.4.R1 software was used to conduct a visual analysis of the screened literature, covering core dimensions such as the trend of publication volume, author/institution/country collaboration networks, keyword timelines, keyword clustering, keyword bursts, keyword cooccurrence, and highly cited literature. Results A total of 2 135 Chinese and 2 151 English literature on naringin were retrieved. The publication volume of Chinese literature showed a development trend of “first rising and then stabilizing”, while the publication volume of English literature continued to increase. The top countries in terms of the proportion of English literature publication volume were China, India, and the United States, and there was a certain degree of cooperation among the top 10 countries. The research institutions of English literature had close cooperation, while the cooperation among the institutions publishing Chinese literature was relatively loose. The core research teams in both Chinese and English literature included the Chen Dan team, Su Weiwei team, and Ahmed, Osama M team. Globally, the research on naringin mainly focused on core directions such as extraction technology, quality control, pharmacological activity, and mechanism of action. Conclusion The research on naringin has remained highly popular over the past 20 years, with research focuses concentrated on its anti-tumor, anti-inflammatory, antioxidant, anti-osteoporosis and osteogenic effects, and metabolic regulation, as well as quality evaluation-related research, laying a foundation for the in-depth development of subsequent research.

R285

国家自然科学基金项目(82304722); 全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号); 湖北省中医药联合基金项目(ZY2025L022); 湖北省自然科学基金咸宁创新发展联合基金项目(2025AFD390)