目的 基于文献综述法、德尔菲法、层次分析法及深圳市慢性阻塞性肺疾病（COPD）真实世界诊疗数据，构建单病种综合评价指标体系。方法 通过系统文献综述整理评价证据，应用德尔菲专家咨询法、层次分析法构建指标体系及评分细则，并参考真实世界数据作为证据补充。结果 21名专家积极性较高（80.95%），权威系数为0.89，专家评分平均变异系数为0.17，一级指标肯德尔协调系数（W）为0.53。评价指标体系共包含6个一级指标、14个二级指标以及23个三级指标。结论 参考真实世界数据并联用多种方法，为指标体系提供了更高等级的证据支撑，实现了单病种临床综合评价方法学的创新突破，为优化临床用药决策提供了循证依据。

Objective Based on the literature review method, Delphi method, hierarchical analysis method and the real-world data of chronic obstructive pulmonary disease(COPD) in Shenzhen, to construct a single-disease comprehensive evaluation index system. Methods The evidence for evaluation was organized through systematic literature review, and the Delphi expert consultation method and hierarchical analysis method were applied to construct the index system and scoring rules, with reference to real-world data as evidence supplement. Results The 21 experts were highly motivated(80.95%), the authority coefficient was 0.89, the average coefficient of variation of the expert ratings was 0.17, and the Kendall's coordination coefficient of the first-level indicator was 0.53. The evaluation indicator system contained a total of six first-level indicators, 14 second-level indicators, and 23 third-level indicators. Conclusion This study refers to real-world data and associates multiple methods to provide a higher level of evidence support for the index system, and achieve an innovative breakthrough in the methodology of comprehensive clinical evaluation of a single disease, providing an evidence-based foundation for optimizing clinical medication decisions.

R974