目的 采用文献计量学的方法对黄芩苷的研究动态进行可视化分析，为未来黄芩苷的临床应用和深入研究提供理论指导。方法 以“黄芩苷”为关键词，检索中国学术期刊全文数据库（CNKI）、Web of Science（WOS） 2个数据库，使用Excel、CiteSpace、VOSviewer等软件，从发文量趋势与国家分布、发文合作、发文作者、发文机构、关键词等层面，对国内外黄芩苷研究状况进行可视化分析。结果 共检索到符合要求的文献10 900篇，其中中文文献6 907篇，英文文献3 993篇。从发文量来看，黄芩苷研究领域热度持续上升，以中国为核心研究力量，同时与美国等国家建立了紧密合作。团队合作方面，国内外均已形成稳定的核心研究团队。机构合作上，以北京中医药大学中药学院等为核心，呈现“核心机构引领，多机构协同”格局。关键词突现与时间线分析表明，国内研究从早期物质基础探索逐步深入，国际研究则聚焦网络药理学、肠道菌群、自噬等前沿交叉领域，二者形成互补研究格局。结论 黄芩苷相关研究持续受到国内外关注，发文量持续增长，中国为核心研究力量且与多国建立紧密合作，形成稳定研究团队。当前聚焦药理机制多向延伸、新型递药系统开发及多组学交叉验证，未来需强化前沿技术融合与临床转化，以进一步挖掘其潜在价值。

Objective To conduct a visual analysis of the research dynamics of baicalin using bibliometric methods, so as to provide theoretical guidance for the clinical application and in-depth research of baicalin in the future. Methods Taking baicalin as the keyword, literature retrieval was performed in two databases, namely China National Knowledge Infrastructure (CNKI) and Web of Science (WOS). Software including Excel, CiteSpace, and VOSviewer was used to conduct a visual analysis of domestic and international research on baicalin from the perspectives of literature output trend and national distribution, collaborative publication patterns, contributing authors, research institutions, and keywords. Results A total of 10 900 eligible literatures were retrieved, including 6 907 Chinese literatures and 3 993 English literatures. From the perspective of literature output, the research field of baicalin has maintained a continuous upward trend in research enthusiasm. China is the core research force and has established close cooperative relationships with countries such as the United States. In terms of team collaboration, stable core research teams have been formed both domestically and internationally. Regarding institutional cooperation, with institutions like the School of Chinese Materia Medica, Beijing University of Chinese Medicine as the core, a pattern of “led by core institutions and collaborated by multiple institutions” has been presented. The analysis of keyword bursts and timelines showed that domestic research has gradually deepened from the early exploration of material basis, while international research has focused on cutting-edge interdisciplinary fields such as network pharmacology, gut microbiota, and autophagy. These two research directions have formed a complementary research pattern. Conclusion Baicalin-related research has continued to attract attention at home and abroad, with a steady growth in literature output. China serves as the core research force and has established close cooperation with many countries, forming stable research teams. Currently, the research focuses on the multi-directional expansion of pharmacological mechanisms, the development of novel drug delivery systems, and cross-validation based on multi-omics. In the future, it is necessary to strengthen the integration of cutting-edge technologies and clinical transformation to further explore the potential value of baicalin

R285.5

国家自然科学基金资助项目（82174065）；云南省朱兆云院士工作站（202405AF140128）；云南省科技厅社会发展专项-重点研发计划项目（202303AC100025）；云南省生物医药专项-重大科技专项计划（202302AA310031）