目的 运用文献计量学与可视化分析技术，系统梳理刺五加领域的研究演进脉络，客观辨识其研究热点与前沿转向，旨在为该领域的未来基础研究战略规划与产业高质量发展提供科学、直观的决策依据。方法 检索中国学术期刊全文数据库（CNKI）和Scopus数据库中2000年1月—2025年8月发表的刺五加相关研究文献。经由筛选与去重后，采用CiteSpace、VOSviewer等软件工具对纳入文献的年份、国家、机构、作者、期刊及关键词等要素进行可视化分析。结果 共纳入中文文献1 166篇，英文文献333篇。该领域年发文量总体呈“上升-回落-恢复”的动态趋势。中国处于研究的核心地位，国际合作仍有较大提升空间。黑龙江中医药大学是最高产机构，刘树民和卢芳分别为中、英文文献的高产作者。《中成药》和Journalof Ethnopharmacology分别是中、英文文献中刊载量最高的期刊。刺五加研究主题主要聚焦于有效成分的提取纯化、药理机制研究及质量评价3个方向，其研究模式正从传统的药效验证向多组学整合的系统机制研究转变。结论 当前刺五加相关研究处于稳步回升阶段，未来预计将保持积极态势，在研发过程中中国发挥着重要作用，研究地域性特征明显。刺五加研究热点集中于其治疗神经退行性疾病、抗肿瘤、抗疲劳、免疫调节等作用的机制探索。未来研究将更注重以药用部位与活性成分为导向，聚焦于新成分发现、提取工艺优化、药理机制深入解析及新药效功能的发掘，从而提升刺五加的综合利用价值。多组学整合策略、先进分析技术及系统生物学方法将在推动该领域实现从资源开发到临床转化的全链条创新中发挥关键作用。

Objective By using bibliometrics and visual analysis technology, this paper systematically combs the research evolution of Acanthopanax senticosus field, objectively identifies its research hotspots and frontier shifts, and aims to provide scientific and intuitive decision-making basis for future basic research strategic planning and high-quality industrial development in this field. Methods By retrievaling CNKI and Scopus databases from January 1st, 2000 to August 1 st, 2025, the Chinese and English literatures related to A. senticosus were collected. After screening and deduplication, CiteSpace, VOSviewer and other software were used to conduct visual analysis, focusing on the year of publication, country, institution, author, journal of publication, citation frequency of literature, keywords and so on. Results A total of 1 166 and 333 articles were included in Chinese and English databases, respectively. The annual number of publications in this field generally shows a dynamic trend of “rise-fall-recovery”. China is at the core of the research, and there is still much room for improvement in international cooperation. Heilongjiang University of Traditional Chinese Medicine is the highest-yielding institution. Liu Shumin and Lu Fang are the high-yielding authors of Chinese and English literature respectively. The journals with the largest number of articles are Chinese Patent Medicine and Journal of Ethnopharmacology, respectively. Research on A. senticosus mainly focuses on the extraction and purification of active ingredients, pharmacological mechanism research and quality control evaluation. Its research model is changing from traditional pharmacodynamic verification to multi-omics integrated system mechanism research. Conclusion At present, the number of research papers on A. senticosus is in the stage of recovery, and the future is predicted to be positive, and China plays an important role in this field, and the regional characteristics of the research are obvious.The research hotspots of A. senticosus focus on the mechanism of its treatment of neurodegenerative diseases, anti-tumor, anti-fatigue, immune regulation and so on. It is speculated that the future research trend will be based on the theme of medicament portions and active components. In the future, more attention will be paid to the discovery of new components, the optimization of extraction process, the in-depth analysis of pharmacological mechanism and the discovery of new pharmacological functions guided by medicament portions and active components, so as to enhance the comprehensive utilization value of A. senticosus. Multi-omics integration strategy, advanced analytical techniques and systems biology methods will play a key role in promoting the whole chain innovation from resource development to clinical transformation in this field.

R285.5

国家重点研发计划（2022YFC3501705）；上海市领军人才计划（SHLJ2019100）；上海市启明星计划扬帆专项项目（24YF2741000）