酸枣仁Ziziphi Spinosae Semen为传统药食同源中药，具有养心补肝、宁心安神、敛汗生津之功效。现代药理研究表明，其具有镇静催眠、抗焦虑、抗抑郁、改善认知与记忆、抗肿瘤、保肝、保护心血管等多种药理作用。药对配伍是提升酸枣仁临床疗效的关键手段，例如酸枣仁配茯苓可调和心脾，配伍远志则能交通心肾。除其生品与炒品的炮制配伍外，酸枣仁还常与茯苓、远志、五味子、合欢花、柏子仁等药物配伍使用，以实现协同增效、拓展临床应用范畴的目的。综述酸枣仁的药理作用，及其常用药对的中医配伍理论与现代研究进展，以期为酸枣仁及其药对的后续研究与临床应用提供理论支撑与实践参考。

Ziziphus jujuba is a traditional medicinal and food-originating Chinese herb with the functions of nourishing the heart, strengthening the liver, calming the mind, and soothing the nerves, as well as promoting sweating and generating body fluids. Modern pharmacological studies have shown that it has various pharmacological effects such as sedation and hypnotic, anti-anxiety and antidepression, improvement of cognition and memory, anti-tumor, liver protection, and cardiovascular protection. The combination of medicinal pairs is a key means to enhance the clinical efficacy of Z. jujuba. For example, Z. jujuba combined with Poria cocos can harmonize the heart and spleen, and combined with Polygala tenuifolia. can connect the heart and kidney. Besides the processing combinations of raw and roasted products, Z. jujuba is often used in combination with Poria cocos, P. tenuifolia, Schisandra chinensis, Albizia julibrissin, and Platycladus orientalis, etc., to achieve synergistic effects and expand the clinical application scope. This article reviews the pharmacological effects of Z. jujuba and the traditional Chinese medicine pairing theory and modern research progress of its commonly used medicinal pairs, with the aim of providing theoretical support and practical references for the subsequent research and clinical application of Z. jujuba and its medicinal pairs.

R285.5;R289.1

国家中医药百千万人才支持计划-岐黄学者(国中医药人教发[2018]284号); 全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号); 全国名中医传承工作室建设项目(国中医药人教函[2022]245号); 中西医防治重大疾病河南省协同创新中心(教科技[2023]413号)