目的 运用CiteSpace软件对柴胡毒性相关文献开展可视化分析，全面梳理近年来该领域的研究动态与发展脉络，明确研究热点及未来潜在发展趋势，为柴胡临床安全、合理用药提供科学参考依据。方法 检索2005年1月1日—2025年5月15日发表于中国学术期刊全文数据库（CNKI）、万方数据、维普核心数据库及Web of Science、PubMed核心数据库的柴胡毒性相关文献，采用NoteExpress软件剔除不符合纳入标准的文献后，运用CiteSpace可视化软件，对筛选后文献的发文量、发文国家、发文机构、核心作者及关键词进行系统性梳理与分析。结果 共检索获得符合标准的中文文献152篇、英文文献89篇；中文文献发文量呈先升后降趋势，波动较为明显，英文文献发文量则呈现稳步缓慢上升态势；该领域发文量最多的国家为中国；中文文献发文机构中，山东中医药大学发文量居首，英文文献则以韩国大邱大学发文量最多；中外学者中，孙蓉（Sun Rong）的发文量均位居第一；关键词分析显示，中文研究热点主要集中于柴胡毒性成分的筛选与明确，英文研究则重点聚焦于柴胡毒性作用机制的深入探讨。结论 柴胡毒性相关研究在国外正逐步兴起，核心研究方向为毒性机制；目前已明确柴胡皂苷A与柴胡皂苷D是柴胡的核心毒性成分，柴胡毒理学研究的前沿已转向毒性机制的深度挖掘，其中内质网应激与脂质过氧化是当前该领域的研究热点。

Objective To conduct a visual analysis of the literature related to the toxicity of Bupleuri Radix using CiteSpace software, comprehensively sort out the research trends and development context in this field in recent years, clarify the research hotspots and potential future development trends, and provide a scientific reference basis for the safe and rational clinical use of Bupleuri Radix. Methods Relevant literature on the toxicity of Bupleuri Radix published from January 1, 2005 to May 15, 2025 in the China National Knowledge Infrastructure(CNKI), Wanfang Data, VIP Core Database, Web of Science, and PubMed Core Database were retrieved. After eliminating the literature that did not meet the inclusion criteria using NoteExpress software, CiteSpace visualization software was used to systematically sort out and analyze the publication volume, publishing countries, publishing institutions, core authors, and keywords of the selected literature. Results A total of 152 Chinese and 89 English articles that met the criteria were retrieved. The publication volume of Chinese literature showed an initial increase followed by a decrease, with significant fluctuations, while the publication volume of English literature showed a steady and slow upward trend. China was the country with the highest publication volume in this field. Among Chinese literature, Shandong University of Traditional Chinese Medicine had the highest publication volume, while among English literature, Daegu University in South Korea had the highest publication volume. Among both Chinese and foreign scholars, Sun Rong had the highest publication volume. Keyword analysis revealed that the research hotspots in Chinese literature mainly focused on the screening and identification of toxic components of Bupleuri Radix, while English literature focused on in-depth exploration of the toxicity mechanism of Bupleuri Radix. Conclusion Research on the toxicity of Bupleuri Radix is gradually emerging abroad, with the core research direction being the toxicity mechanism. It has been confirmed that saikosaponin A and saikosaponin D are the core toxic components of Bupleuri Radix. The frontier of Bupleuri Radix toxicology research has shifted to the in-depth exploration of the toxicity mechanism, with endoplasmic reticulum stress and lipid peroxidation being the current research hotspots in this field.

G350;R282.71

国家自然科学基金资助项目(H2805-82060717); 江西省重点项目(2024BBI91014); 江西省技术创新引导类计划(2023KZI01003); 江西省中医药标委会2024年标准化项目(2024A001); 江西省卫生健康委科技创新重点项目(2025ZD001); 中药药性变化创新团队(NYTD202202)