目的 从知识图谱角度运用文献计量学对毒性中药的脉络、热点与趋势进行全面分析，为未来该领域的深入研究提供科学有益的路径参考。方法 检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、维普生物医学数据库（VIP）、Web of Science（WOS） 4个数据库，检索时间设定为1985年1月1日—2025年6月30日，将文献导入NoteExpress文献管理软件中进行查重和筛选。利用CiteSpace、VOSviewer等软件，从发文趋势、国家分布、发文机构、发文作者、关键词等维度出发，对国内外毒性中药研究进行可视化分析。结果 共检索到符合要求的中文文献1 676篇，英文文献3 679篇。中国为英文文献发文量与中心性最高的国家；南京中医药大学与Beijing University of Chinese Medicine（北京中医药大学）分别为中、英文发文量最高的机构；肖小河、Liu Zhilong（刘志龙）分别为中、英文发文量最高的作者。毒性中药研究目前处于持续发展阶段，研究整体热度较高，中、英文文献在研究热点领域的分布上存在一定重合之处，均涉及对机制的探讨与研究。结论 毒性中药领域的研究正不断拓展和深入，早期研究聚焦于传统药用资源的基础认知与安全性初判，后期研究逐步向多维度、跨学科方向延伸。

Objective From the perspective of knowledge graph, bibliometrics was applied to conduct a comprehensive analysis of the context, hotspots, and trends in toxic traditional Chinese medicine (TCM) research, aiming to provide scientific and useful path references for in-depth studies in this field in the future. Methods Literatures were retrieved from four databases, including CNKI, Wanfang Data, VIP Chinese Journal Database, and Web of Science (WOS), with the retrieval period set from January 1, 1985 to June 30, 2025. The retrieved literatures were imported into NoteExpress, a literature management software, for duplicate checking and screening. Software such as CiteSpace and VOSviewer were used to perform visual analysis on domestic and international toxic TCM research from multiple dimensions, including publication trends, national distribution, research institutions, authors, and keywords. Results A total of 1 676 Chinese literatures and 3 679 English literatures meeting the requirements were retrieved. China ranked first in both the number of English publications and centrality. Nanjing University of Chinese Medicine and Beijing University of Chinese Medicine were the institutions with the highest number of publications in Chinese and English, respectively. Xiao Xiaohe and Liu Zhilong were the most prolific authors in Chinese and English, respectively. Toxic TCM research is currently in a stage of continuous development with high overall research enthusiasm. There is a certain overlap in the distribution of research hotspots between Chinese and English literatures, both involving the exploration and research of mechanisms. Conclusion Research in the field of toxic TCM is constantly expanding and deepening. Early studies focused on the basic cognition of traditional medicinal resources and preliminary safety assessment, while later studies have gradually evolved towards multi-dimensional and interdisciplinary directions.

R285.5

国家社科基金冷门绝学项目（21VJXG038）；江苏省中医疫病研究中心开放课题（JSYB2024KF28）；江苏省中医流派研究院开放课题一般项目（JSZYLP2024040，JSZYLP2024042）；无锡市卫生健康委科技计划（M202329，T202549，M202552）；无锡市中医药科技发展专项重点项目（ZYZD202404）；无锡市名中医工作室（锡中医〔 2023〕 2号〈11〉）