乳腺增生是育龄期女性的常见良性疾病，其发病率逐年攀升，严重影响患者身心健康。现代医学认为其病理核心为雌孕激素失衡，而中医学则将其归为“乳癖”，指出肝郁气滞是其发病之始、病机之本。因此，疏肝解郁是中医论治乳腺增生的核心法则。近年来，疏肝解郁类方药如柴胡疏肝散、逍遥丸（散）及其众多衍生制剂（如乳癖消、乳核散结片、红金消结胶囊等），在调节神经内分泌、抑制乳腺增生、缓解临床症状方面展现出独特优势。从中医病机治法、作用机制、临床应用3个维度系统评述该领域研究进展，为疏肝解郁类中成药防治乳腺增生提供学术支撑。

Hyperplasia of mammary glands（HMG） is a common benign disease in women of childbearing age. Its incidence is increasing year by year, which seriously affects the physical and mental health of patients. Modern medicine believes that its pathological core is the imbalance of estrogen and progesterone, while traditional Chinese medicine classifies it as breast lump, pointing out that liver depression and qi stagnation are the beginning of its pathogenesis. Therefore, soothing liver and relieving depression is the core rule of traditional Chinese medicine in the treatment of HMG. In recent years, soothing liver and relieving depression prescriptions such as Chaihu Shugan Powder, Xiaoyao Pill（Powder） and many derivative preparations（such as Rupixiao, Ruhe Sanjie Tablets, Hongjin Xiaojie Capsules, etc.） have shown unique advantages in regulating neuroendocrine, inhibiting HMG and relieving clinical symptoms. This paper will systematically review the research progress in this field from the three dimensions of TCM pathogenesis, mechanism of action and clinical application, so as to provide academic support for the prevention and treatment of HMG by soothing liver and relieving depression Chinese patent medicines.

R285.5

国家自然科学基金资助项目(82060733); 江西中医药大学重点学科建设项目(2024jzzdxk001); 中西医结合江西省一流学科(zxyylxk20220103); 校级研究生创新专项资金(XJ-S202414)