目的 基于文献计量学总结分析重楼皂苷研究现状及热点，为今后该领域的研究和理论发展提供参考。方法 检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、维普生物医学数据库（VIP）和Web of Science核心数据库自建库以来—2024年12月31日发表的重楼皂苷相关文献，应用R语言和CiteSpace软件对整体产出和主题、研究热点分布及趋势，以及英文文献引文情况进行可视化分析。结果 分别纳入1 033和415篇与重楼皂苷相关的中、英文文献，发文量总体呈逐年上升趋势，中国在该研究领域占据核心地位。关于重楼皂苷的国内外研究主要集中在抗肿瘤相关的药理机制、协同给药、逆转耐药，并且靶向抗癌纳米粒成为新兴研究领域。结论 重楼皂苷近年来研究热度不断上升，抗肿瘤是重楼皂苷的主要研究热点，生物工程合成、靶向纳米制剂、毒性研究等可能是重楼皂苷未来新的研究方向。

Objective To conduct a bibliometric analysis of the research status and research hotspots of polyphyllin, and to quickly summarize the current research and provide reference for future research and theoretical development in this field. Methods The related literatures of polyphyllin published in CNKI, Wanfang, VIP Chinese database and Web of Science from the establishment of the database to December 31, 2024 were searched. The R language and CiteSpace software were used to visualize the overall output and theme, the distribution and trend of research hotspots, and the citation of English literature. Results A total of 1 033 and 415 Chinese and English literatures were included in the literature search results related to polyphyllin, respectively. The number of publications showed an overall upward trend. China occupied the core position in this study, and international cooperation was weak. The research on polyphyllin at home and abroad mainly focuses on the pharmacological mechanism related to anti-tumor, synergistic administration, reversal of drug resistance, and targeted anticancer nanoparticles have become an emerging research field. Conclusion The research heat of polyphyllin has been increasing in recent years, and anti-tumor is the main research hotspot of polyphyllin. Bioengineering synthesis, targeted nano-preparation and toxicity research may be the new research directions of polyphyllin in the future.

G350;R284

中央高校基本科研业务费专项资金项目(2020-JYB-ZDGG-046); 中华中医药学会青年人才托举工程资助项目(2021-QNRC2-A03)