器官纤维化是多种慢性疾病进展至终末期的共同病理表现，以细胞外基质过度沉积、正常组织结构被纤维瘢痕替代为核心特征，严重时可诱发器官功能衰竭，且当前缺乏特效治疗药物。小檗碱作为中药黄连的核心活性成分，传统上多用于治疗消化道病症，近年研究证实其还展现出抗炎、调控代谢等多元药理活性，在抗纤维化领域的研究价值日益受到关注。采用文献计量学方法，系统检索中国学术期刊全文数据库（ CNKI）及Web of Science核心合集（ WOSCC）中近20年的小檗碱抗纤维化领域中、英文文献，借助CiteSpace 6.4.R1软件对文献数据进行挖掘与可视化分析，明确小檗碱抗器官纤维化的研究热点与发展方向。基于上述分析，进一步系统阐述小檗碱针对肝脏、肾脏、心脏、肺脏等主要靶器官发挥抗纤维化作用的具体机制，为该领域的深入研究与临床转化提供理论依据。

Organ fibrosis is a common pathological manifestation of various chronic diseases progressing to the terminal stage, characterized by excessive extracellular matrix deposition and replacement of normal tissue structure by fibrous scars. In severe cases, it can induce organ failure, and there is currently a lack of specific therapeutic drugs. Berberine, as the core active component of the traditional Chinese medicine Coptis chinensis, has traditionally been used to treat digestive tract disorders. Recent studies have confirmed that it also exhibits multiple pharmacological activities such as anti-inflammation and metabolic regulation, and its research value in the field of anti-fibrosis has increasingly attracted attention. This study used bibliometric methods to systematically search for Chinese and English literature on berberine's anti-fibrotic effects in the China National Knowledge Infrastructure (CNKI) and Web of Science Core Collection (WOSCC) over the past 20 years. The CiteSpace 6.4.R1 software was used to mine and visualize the literature data to identify the research hotspots and development directions of berberine's anti-organ fibrosis. Based on the above analysis, this study further systematically expounds the specific mechanisms by which berberine exerts anti-fibrotic effects on major target organs such as the liver, kidneys, heart, and lungs, providing a theoretical basis for in-depth research and clinical translation in this field.

Q344.5;R285.5

黑龙江省自然科学基金资助项目（ LH2020H100）；黑龙江省中医药科研资助项目（ ZHY2023-160）；黑龙江省中医药科研资助项目（ZHY2022-182）；黑龙江省中医药科研资助项目（ZHY2020-136）