溃疡性结肠炎（UC）作为一种病因尚未明确的慢性非特异性炎症性肠病，其慢性易复发的特性已对患者身心健康构成严重威胁。其病因病机复杂，涉及免疫失衡、肠道菌群失调、肠道屏障功能受损及遗传、环境等多因素交互作用。近年研究证实，糖酵解作为关键代谢途径，在UC的发生发展中扮演重要角色，其转运蛋白及关键酶的异常激活可增强糖酵解代谢流，进而影响UC的病理进程。基于此，靶向调控糖酵解代谢通路为UC治疗提供了新的潜在策略。中医药治疗UC历史悠久且经验丰富，不仅能有效缓解临床症状，更具备安全性高、复发率低等显著优势。研究表明，中药可通过调控糖酵解相关转运蛋白、关键酶及上下游信号通路，干预糖酵解代谢途径，最终实现恢复UC免疫细胞平衡、减轻肠道炎症反应及促进肠黏膜屏障修复的多重治疗效应。通过系统梳理糖酵解与UC的关联，以及近年中药活性成分、单味中药及中药复方通过调控糖酵解代谢途径治疗UC的研究进展，旨在为中药临床治疗UC提供新的思路与理论依据。

Ulcerative colitis（UC）, a chronic non-specific inflammatory bowel disease with an unclear etiology, has posed a serious threat to patients’ physical and mental health due to its chronic and relapsing nature. Its pathogenesis is complex, involving the interaction of multiple factors such as immune imbalance, intestinal flora disorder, impaired intestinal barrier function, as well as genetics and environment. Recent studies have confirmed that glycolysis, as a key metabolic pathway, plays an important role in the occurrence and development of UC. The abnormal activation of its transporters and key enzymes can enhance glycolytic metabolic flow, thereby affecting the pathological process of UC. Based on this, targeted regulation of glycolytic metabolic pathways provides a new potential strategy for the treatment of UC. Traditional Chinese medicine has a long history and rich experience in the treatment of UC, which can not only effectively relieve clinical symptoms, but also has significant advantages such as high safety and low recurrence rate. Studies have shown that traditional Chinese medicine can intervene in the glycolytic metabolic pathway by regulating glycolysisrelated transporters, key enzymes and upstream and downstream signaling pathways, and finally achieve multiple therapeutic effects of restoring the balance of immune cells in UC, reducing intestinal inflammatory response and promoting the repair of intestinal mucosal barrier. This article systematically reviews the association between glycolysis and UC, as well as the research progress in the treatment of UC with active components of traditional Chinese medicine, single traditional Chinese medicine and traditional Chinese medicine compounds by regulating glycolytic metabolic pathways, aiming to provide new ideas and theoretical basis for the clinical treatment of UC with traditional Chinese medicine.

R285.5

河南中医药学科领军人才项目(豫卫中医函[2021]8号); 张仲景传承与创新专项(GZY-KJS-2022-041-1); 河南省中医药科学研究专项课题(2023ZY2071)